exRNAdisease

Entry Detail

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General Information

Database ID: exR0231909 RNA Name: hsa-miR-200b-3p RNA Type: miRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 1167160 End Site(bp): 1167181 External Links: hsa-miR-200b-3p

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CHD9 chr16 53055033 53329150 + KLF3 chr4 38664197 38701517 + NRBP1 chr2 27427790 27442259 + SHCBP1 chr16 46578591 46621379 - SRP72 chr4 56467617 56503681 + THAP2 chr12 71664301 71680644 + VMP1 chr17 59707192 59842255 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001186 chr21 35475133 35475818 + hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0001486 chr5 56526672 56527148 + hsa_circ_0000552 chr14 71880664 71948928 + hsa_circ_0001358 chr3 169694733 169706147 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC024940.6 chr12 31280422 31280895 - AC092295.2 chr19 36489649 36491040 + AC116913.1 chr15 66488658 66492109 - AF254983.1 chr21 10482738 10605716 + AL049840.4 chr14 103694516 103695050 - LINC00667 chr18 5237826 5290608 + MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + SNHG22 chr18 49814023 49851059 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.