exRNAdisease

Entry Detail

---



General Information

Database ID: exR0231969 RNA Name: hsa-miR-221-3p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 45746180 End Site(bp): 45746202 External Links: hsa-miR-221-3p

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACVR2B chr3 38453890 38493142 + AP3M1 chr10 74120255 74151063 - DNAJC14 chr12 55820960 55830824 - EFNA1 chr1 155127876 155134899 + KDSR chr18 63327726 63367228 - MPZL1 chr1 167721192 167791919 + PPIL1 chr6 36854827 36874803 - TBL1X chrX 9463295 9741037 + TUB chr11 8019244 8106112 + ZBTB5 chr9 37438102 37465450 - DDIT4 chr10 72273924 72276036 + FUS chr16 31180110 31194871 + MAPRE1 chr20 32819954 32850405 + RIPOR2 chr6 24804282 25042170 - SP4 chr7 21428043 21514822 + TUBA1B chr12 49127782 49131397 - ZNF649 chr19 51889235 51905040 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001247 chr22 46125304 46136418 + hsa_circ_0000670 chr16 9199043 9199243 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC020978.7 chr16 68224713 68227734 + AC022150.4 chr19 52650437 52653284 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - GAS5 chr1 173858559 173868882 - NEAT1 chr11 65422774 65445540 + TUG1 chr22 30969245 30979395 + TYMSOS chr18 630886 658340 - Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.