Entry Detail


General Information

Database ID:exR0232570
RNA Name:hsa-miR-4449
RNA Type:miRNA
Chromosome:chr4
Starnd:+
Coordinate:
Start Site(bp):52712720End Site(bp):52712741
External Links:hsa-miR-4449



Disease Information

Disease Name:Benign bone and soft tissue tumor
Disease Category:Other Diseases
MeSH ID:
Type:
Alias:



Expression Detail

GEO ID:GSE124158
Description:A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes
Experimental Design:Cancer vs Control
Case Disease Type:Benign bone and soft tissue tumor
Case Disease SubType:NA
Case Sample:Benign bone and soft tissue tumor
Control Sample:Healthy
Number of Case:339
Number of Control:275
Number of Samples:614





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACAA1
chr3
38103129
38137242
-
FTSJ1
chrX
48476021
48486364
+
PPFIA3
chr19
49119544
49151026
+
RBM10
chrX
47145221
47186813
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC020928.1
chr19
36773112
36777078
+
Display:



Experiment Detail

GEO ID:GSE124158
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2512
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30898996
Title:A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes
Author:Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T
Journal:Nat Commun. 2019 Mar 21;10(1):1299.
Description:we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.