exRNAdisease

Entry Detail

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General Information

Database ID: exR0232613 RNA Name: hsa-miR-4492 RNA Type: miRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 118910765 End Site(bp): 118910781 External Links: hsa-miR-4492

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AGFG1 chr2 227472152 227561214 + NRARP chr9 137299631 137302271 - RHOA chr3 49359145 49412998 - AATF chr17 36948954 37056871 + ANOS1 chrX 8528874 8732137 - DDRGK1 chr20 3190350 3204685 - FBXL3 chr13 76992598 77027195 - LEPR chr1 65420652 65641559 + MDP1 chr14 24213943 24216070 - MELTF chr3 196988621 197029817 - NCKAP5L chr12 49791146 49828750 - PKN3 chr9 128702503 128720916 + RNF149 chr2 101271219 101308701 - SH3BP2 chr4 2793071 2841098 + SNAPC2 chr19 7920338 7923250 + SOCS2 chr12 93569814 93583487 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL096870.2 chr14 24209646 24215987 - Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.