exRNAdisease

Entry Detail

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General Information

Database ID: exR0232792 RNA Name: hsa-miR-4700-5p RNA Type: miRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 120723202 End Site(bp): 120723223 External Links: hsa-miR-4700-5p

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand GAPDH chr12 6534512 6538374 + SEC61A1 chr3 128051641 128071683 + UNC119B chr12 120710458 120723640 + HADH chr4 107989714 108035175 + MFSD10 chr4 2930561 2934834 - ORMDL1 chr2 189770267 189784364 - PDIA6 chr2 10783391 10837977 - SAC3D1 chr11 65040901 65044828 + TPT1 chr13 45333471 45341370 - WDR1 chr4 10074339 10116949 - miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.