exRNAdisease

Entry Detail

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General Information

Database ID: exR0232806 RNA Name: hsa-miR-4709-5p RNA Type: miRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 74480175 End Site(bp): 74480196 External Links: hsa-miR-4709-5p

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BCORL1 chrX 129981107 130058083 + CBX2 chr17 79778148 79787983 + CTNND1 chr11 57753243 57819546 + DNAJB6 chr7 157335381 157417439 + ERP29 chr12 112013348 112023449 + LAMC1 chr1 183023420 183145592 + ARID4B chr1 235131634 235328219 - CLSTN3 chr12 7129698 7158945 + DHX16 chr6 30653119 30673006 - GFM2 chr5 74721206 74767147 - HNRNPL chr19 38836388 38852347 - HOXB13 chr17 48724763 48729178 - HSP90AA1 chr14 102080738 102139699 - IDH1 chr2 208236227 208266074 - IREB2 chr15 78437431 78501453 + MKKS chr20 10401009 10434222 - MSH3 chr5 80654652 80876815 + NPC2 chr14 74476192 74494177 - PABPC1 chr8 100685816 100722809 - PODXL chr7 131500262 131558217 - PRDX5 chr11 64318121 64321811 + SCAF8 chr6 154733325 154834244 + TIAM2 chr6 154832697 155257723 + UGP2 chr2 63840940 63891562 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005479.1 chr14 74474007 74474864 - Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.