exRNAdisease

Entry Detail

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General Information

Database ID: exR0233140 RNA Name: hsa-miR-541-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 101064504 End Site(bp): 101064528 External Links: hsa-miR-541-5p

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: NA miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001880 chr9 110084263 110087285 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC022150.4 chr19 52650437 52653284 - AC239868.1 chr1 149861271 149862504 + FGD5-AS1 chr3 14920347 14948424 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + PCBP2-OT1 chr12 53464468 53465057 + SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.