exRNAdisease

Entry Detail

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General Information

Database ID: exR0233333 RNA Name: hsa-miR-589-5p RNA Type: miRNA Chromosome: chr7 Starnd: - Coordinate: Start Site(bp): 5495873 End Site(bp): 5495894 External Links: hsa-miR-589-5p

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007192.1 chr19 18153158 18178117 + ATP6V0D1 chr16 67438014 67481181 - FXYD3 chr19 35115879 35124324 + JPT2 chr16 1678256 1702280 + MICU1 chr10 72367327 72626191 - NFIX chr19 12995608 13098796 + PACS1 chr11 66070272 66244744 + PIK3R2 chr19 18153163 18170532 + RNF169 chr11 74748849 74842413 + SEC61A1 chr3 128051641 128071683 + WDR45B chr17 82614562 82648553 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001134 chr20 21319681 21324846 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC027290.2 chr12 122865335 122867021 + KCNQ1OT1 chr11 2608328 2699994 - MALAT1 chr11 65497688 65506516 + Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.