exRNAdisease

Entry Detail

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General Information

Database ID: exR0233489 RNA Name: hsa-miR-654-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 101040234 End Site(bp): 101040255 External Links: hsa-miR-654-5p

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BCL9L chr11 118893875 118925608 - ATP11A chr13 112690329 112887168 + PHB chr17 49404049 49414905 - ZDHHC3 chr3 44915257 44976185 - PKM chr15 72199029 72231822 - ATXN7L3 chr17 44191805 44200113 - SH3PXD2A chr10 103594027 103855543 - ITGA5 chr12 54395261 54419266 - TP53 chr17 7661779 7687550 - CBFA2T3 chr16 88874858 88977207 - CS chr12 56271699 56300391 - LY6E chr8 143017982 143023832 + SPINT1 chr15 40844018 40858207 + AGTRAP chr1 11736084 11754802 + URM1 chr9 128371361 128392016 + BCL7A chr12 122019422 122062044 + MEF2D chr1 156463727 156500779 - DHCR24 chr1 54849627 54887195 - JADE2 chr5 134524312 134583230 + LSM12 chr17 44034328 44067619 - ZMIZ1 chr10 79068966 79316528 + TOB2 chr22 41433494 41446801 - ACTN4 chr19 38647649 38731589 + XPO6 chr16 28097979 28211920 - KMT2D chr12 49018975 49059774 - SMAD3 chr15 67063763 67195169 + BCAM chr19 44809071 44821421 + IGF2BP1 chr17 48997385 49056145 + GID4 chr17 18039408 18068405 + NID1 chr1 235975830 236065109 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0000642 chr15 80390757 80415142 + hsa_circ_0000816 chr17 80521229 80526077 + hsa_circ_0000643 chr15 80412669 80415142 + hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC239868.1 chr1 149861271 149862504 + AL035458.2 chr20 34234840 34281173 - AL356488.2 chr1 109100193 109100619 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.