exRNAdisease

Entry Detail

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General Information

Database ID: exR0233754 RNA Name: hsa-miR-6835-3p RNA Type: miRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 34240714 End Site(bp): 34240736 External Links: hsa-miR-6835-3p

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HMGA1 chr6 34236873 34246231 + SASH1 chr6 148272304 148552048 + HAPLN1 chr5 83637805 83720855 - MAMDC2 chr9 70043848 70226972 + PABPN1 chr14 23321289 23326185 + PTPRF chr1 43525187 43623666 + PUM1 chr1 30931506 31065991 - ZBTB32 chr19 35704558 35717038 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000591 chr15 41961025 41962156 + hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0000018 chr1 15860731 15863309 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011815.1 chr18 35280867 35290201 - AC020978.7 chr16 68224713 68227734 + AC021078.1 chr5 149494314 149504670 - AL137129.1 chr14 61734138 61776260 + AL158825.2 chr9 75009828 75016036 - FGD5-AS1 chr3 14920347 14948424 - KCNQ1OT1 chr11 2608328 2699994 - MIR17HG chr13 91347820 91354579 + MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + TERC chr3 169764520 169765060 - XIST chrX 73820649 73852723 - ZFAS1 chr20 49278178 49299600 + Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.