exRNAdisease

Entry Detail

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General Information

Database ID: exR0233943 RNA Name: hsa-miR-7705 RNA Type: miRNA Chromosome: chr8 Starnd: - Coordinate: Start Site(bp): 100703002 End Site(bp): 100703024 External Links: hsa-miR-7705

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CTNND1 chr11 57753243 57819546 + FSTL1 chr3 120392293 120450993 - CTNNA1 chr5 138610967 138935034 + EIF3H chr8 116642130 116766925 - MLF1 chr3 158571163 158607252 + NTPCR chr1 232950605 232983882 + PABPC1 chr8 100685816 100722809 - PABPC3 chr13 25095868 25099254 + RPL27 chr17 42998273 43002959 + RPLP2 chr11 809965 812880 + RPP30 chr10 90871716 90908553 + RPS6 chr9 19375715 19380236 - SRSF1 chr17 58000919 58007346 - TTYH2 chr17 74213571 74262020 + miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.