exRNAdisease

Entry Detail

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General Information

Database ID: exR0233950 RNA Name: hsa-miR-7847-3p RNA Type: miRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 1880105 End Site(bp): 1880125 External Links: hsa-miR-7847-3p

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MAVS chr20 3846799 3876123 + ACTB chr7 5527148 5563784 - CRELD1 chr3 9933816 9945406 + EVC chr4 5711201 5814305 + HNRNPUL2 chr11 62712630 62727457 - HPRT1 chrX 134460165 134520513 + MRPL35 chr2 86199355 86213790 + MYC chr8 127735434 127742951 + PEX19 chr1 160276812 160286348 - RPL10 chrX 154389955 154409168 + RPS15 chr19 1438358 1440494 + SLC25A6 chrX 1386152 1392113 - SRRM2 chr16 2752626 2772538 + TMSB4X chrX 12975110 12977227 + WIPF1 chr2 174559572 174682916 - miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.