Entry Detail


General Information

Database ID:exR0256704
RNA Name:hsa-miR-105-5p
RNA Type:miRNA
Chromosome:chrX
Starnd:-
Coordinate:
Start Site(bp):152394458End Site(bp):152394480
External Links:hsa-miR-105-5p



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ARPP19
chr15
52547045
52569883
-
DNAJB6
chr7
157335381
157417439
+
EXTL2
chr1
100872372
100895179
-
GTF2H5
chr6
158168350
158199344
+
LMBR1
chr7
156668946
156893216
-
MAPKAPK2
chr1
206684944
206734283
+
MCL1
chr1
150574551
150579738
-
MEF2D
chr1
156463727
156500779
-
NRIP1
chr21
14961235
15065936
-
PDPR
chr16
70113626
70162537
+
PIK3R3
chr1
46040140
46133036
-
PYGB
chr20
25248085
25298012
+
RAB22A
chr20
58309715
58367507
+
SLC31A1
chr9
113221544
113264492
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0000987
chr2
30748452
30756180
+
hsa_circ_0001414
chr4
56277780
56284152
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC068768.1
chr12
123262060
123262402
+
AC079781.5
chr7
97851688
97972985
-
AC145207.5
chr17
81878425
81881106
-
CYTOR
chr2
87454781
87636740
+
EPB41L4A-AS1
chr5
112160526
112164818
+
FGD5-AS1
chr3
14920347
14948424
-
GAS5
chr1
173858559
173868882
-
HCG11
chr6
26521709
26527404
+
MALAT1
chr11
65497688
65506516
+
MCF2L-AS1
chr13
112967484
112968824
-
MIR4435-2HG
chr2
111006015
111523376
-
NNT-AS1
chr5
43571594
43603230
-
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
SCAMP1-AS1
chr5
78342365
78360507
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.