Entry Detail


General Information

Database ID:exR0256719
RNA Name:hsa-miR-1181
RNA Type:miRNA
Chromosome:chr19
Starnd:-
Coordinate:
Start Site(bp):10403505End Site(bp):10403525
External Links:hsa-miR-1181



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CDC37
chr19
10391133
10420121
-
CHD7
chr8
60678740
60868028
+
IRS2
chr13
109752695
109786583
-
MAZ
chr16
29806106
29811164
+
PIM1
chr6
37170152
37175428
+
RRP1B
chr21
43659560
43696079
+
ZMIZ1
chr10
79068966
79316528
+
CAMK4
chr5
111223653
111494886
+
ELF1
chr13
40931924
41061440
-
GNAS
chr20
58839718
58911192
+
GSPT1
chr16
11868128
11916082
-
HNRNPA0
chr5
137745651
137754363
-
HNRNPUL2
chr11
62712630
62727457
-
HNRNPUL2-BSCL2
chr11
62690275
62727384
-
IMMT
chr2
86143932
86195770
-
MDFIC
chr7
114922154
115019202
+
PRKAA2
chr1
56645314
56715335
+
RAB21
chr12
71754863
71800286
+
RALY
chr20
33993646
34108308
+
SLC4A4
chr4
71062667
71572087
+
SOX1
chr13
112067149
112071706
+
SPINT2
chr19
38244035
38292615
+
TMEFF1
chr9
100473149
100577636
+
TTC3
chr21
37073226
37203112
+
U2AF1
chr21
43092956
43107587
-
U2AF1L5
chr21
6484623
6499261
-
UBE2D2
chr5
139526431
139628434
+
ZNF282
chr7
149195546
149226238
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC007216.1
chr16
11976851
11977850
-
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.