Entry Detail


General Information

Database ID:exR0256813
RNA Name:hsa-miR-1270
RNA Type:miRNA
Chromosome:chr19
Starnd:-
Coordinate:
Start Site(bp):20399320End Site(bp):20399342
External Links:hsa-miR-1270



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIEF1
chr22
39499432
39518132
+
WIPF2
chr17
40219304
40284136
+
GBA2
chr9
35736866
35749228
-
HIF1AN
chr10
100529072
100559998
+
TCF12
chr15
56918623
57299281
+
CDC42EP2
chr11
65314866
65322417
+
LITAF
chr16
11547722
11636381
-
GRHL2
chr8
101492439
101669726
+
PRLR
chr5
35048756
35230487
-
PATL1
chr11
59636716
59669037
-
CACNG4
chr17
66964707
67033398
+
ZNF652
chr17
49289206
49362473
-
CDC37
chr19
10391133
10420121
-
AGFG1
chr2
227472152
227561214
+
SMG7
chr1
183472216
183598246
+
TRIP6
chr7
100867387
100873454
+
FN1
chr2
215360440
215436073
-
DCBLD2
chr3
98795941
98901695
-
BEND3
chr6
107065182
107115269
-
NACC1
chr19
13116862
13141147
+
TPM4
chr19
16067021
16103002
+
TLNRD1
chr15
81000923
81005788
+
SRGAP2
chr1
206203345
206464443
+
PITPNA
chr17
1517718
1562792
-
FAM78A
chr9
131258076
131276510
-
ATP6V1B2
chr8
20197381
20226819
+
VGF
chr7
101162509
101165569
-
PLAGL2
chr20
32192504
32207743
-
PCDH10
chr4
133149294
133208606
+
B4GALT5
chr20
49632945
49713878
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001247
chr22
46125304
46136418
+
hsa_circ_0001159
chr20
40161688
40179999
-
hsa_circ_0000471
chr13
33091993
33101669
-
hsa_circ_0001666
chr6
170626457
170639638
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC239868.1
chr1
149861271
149862504
+
AC245033.4
chr15
82533175
82540008
-
AP000233.2
chr21
25095022
25103670
+
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
NR2F2-AS1
chr15
96110040
96327361
-
OIP5-AS1
chr15
41283990
41309737
+
SNHG12
chr1
28578538
28583132
-
SNHG8
chr4
118278709
118285316
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.