exRNAdisease

Entry Detail

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General Information

Database ID: exR0256835 RNA Name: hsa-miR-1286 RNA Type: miRNA Chromosome: chr22 Starnd: - Coordinate: Start Site(bp): 20249145 End Site(bp): 20249165 External Links: hsa-miR-1286

Disease Information

Disease Name: Obesity Disease Category: Other Diseases MeSH ID: D009765 Type: Diseases Category/Nutritional and Metabolic Diseases Alias: Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics

Expression Detail

GEO ID: GSE125494 Description: Adipocyte-Derived Exosomal microRNAs in subject serum samples Experimental Design: Disease vs Control Case Disease Type: Obesity Case Disease SubType: NA Case Sample: Obesity Control Sample: Control Number of Case: 8 Number of Control: 3 Number of Samples: 11

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TRIO chr5 14143342 14532128 + TXLNA chr1 32179675 32198285 + CSNK1E chr22 38290691 38318084 - NT5DC2 chr3 52524385 52535054 - ERLIN1 chr10 100150094 100186033 - BTG2 chr1 203305491 203309602 + GOLGA3 chr12 132768914 132829078 - ABCA2 chr9 137007234 137028922 - SSR2 chr1 156009048 156020951 - LUZP1 chr1 23084023 23177808 - RUBCN chr3 197668867 197749727 - CBX6 chr22 38861422 38872249 - KMT2A chr11 118436490 118526832 + LAMTOR1 chr11 72085895 72103297 - PHF12 chr17 28905250 28951771 - NPTX1 chr17 80466834 80477843 - ZXDB chrX 57591652 57597545 + PHLDA3 chr1 201464278 201469237 - NIPSNAP1 chr22 29554808 29581327 - IGDCC3 chr15 65327127 65378002 - TNRC6B chr22 40044817 40335808 + DNAJC30 chr7 73680918 73683453 - ALG10B chr12 38316762 38329721 + RBM4 chr11 66638617 66668374 + ABHD14B chr3 51968510 51983409 - ATXN2L chr16 28823035 28837237 + CPA4 chr7 130293134 130324180 + FGFR1 chr8 38400215 38468834 - HDGF chr1 156742109 156766925 - ATP8B2 chr1 154325553 154351304 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001588 chr6 26204839 26205043 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010327.5 chr19 55216660 55221616 + AC016876.2 chr17 7581964 7584086 - AC124068.2 chr15 89335053 89336161 + DNAAF4-CCPG1 chr15 55355248 55498360 - MIR497HG chr17 7015818 7019659 - NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: GSE125494 Sample Source: Blood Source Fraction: Exosome Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes. RNA Extract protocol: Total RNA was isolated following mirVana's total RNA Isolation kit. RNA library preparation protocol: biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample

Reference

PMID: 31331347 Title: Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs Author: Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ Journal: J Transl Med. 2019 Jul 22;17(1):232. Description: We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.