Entry Detail


General Information

Database ID:exR0256903
RNA Name:hsa-miR-142-3p
RNA Type:miRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):58331245End Site(bp):58331267
External Links:hsa-miR-142-3p



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
BLOC1S6
chr15
45587214
45615945
+
BOD1
chr5
173607145
173616659
-
CUL5
chr11
108008898
108107761
+
ETFRF1
chr12
25195216
25209645
+
SEMA7A
chr15
74409289
74433958
-
TNRC6B
chr22
40044817
40335808
+
ZNF676
chr19
22179089
22215801
-
AL139011.2
chr1
160216800
160285130
-
B2M
chr15
44711487
44718877
+
CCDC126
chr7
23597382
23644708
+
EEF1A1
chr6
73515750
73523797
-
MAST2
chr1
45786987
46036122
+
MBD3
chr19
1573596
1592865
-
MRPL18
chr6
159789812
159798436
+
NDUFA2
chr5
140638740
140647785
-
PEX19
chr1
160276812
160286348
-
PRDX1
chr1
45511036
45523047
-
RPL27
chr17
42998273
43002959
+
SLC35F5
chr2
113705011
113756693
-
SPDL1
chr5
169583636
169604778
+
TMSB4X
chrX
12975110
12977227
+
VPS53
chr17
508668
721717
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000120
chr1
117944807
118009049
+
hsa_circ_0001387
chr4
1902352
1936989
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004687.1
chr17
58330884
58332508
-
AC011815.1
chr18
35280867
35290201
-
AC126365.1
chr17
20788071
20789584
+
FGD5-AS1
chr3
14920347
14948424
-
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
AC138761.1
chr17
22266395
22288301
+
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.