Entry Detail


General Information

Database ID:exR0256907
RNA Name:hsa-miR-144-3p
RNA Type:miRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):28861548End Site(bp):28861567
External Links:hsa-miR-144-3p



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ANXA2
chr15
60347134
60402883
-
ARHGAP18
chr6
129576132
129710177
-
CNOT11
chr2
101252886
101270316
+
EPHA7
chr6
93240020
93419559
-
G3BP2
chr4
75642782
75724525
-
GABPB1
chr15
50275392
50355408
-
IKZF2
chr2
212999691
213152427
-
RAB15
chr14
64945814
64973226
-
ROCK2
chr2
11179759
11348330
-
SGPP1
chr14
63684216
63728065
-
USP47
chr11
11841423
11961887
+
ZNF695
chr1
246945547
247008093
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001376
chr3
194169185
194175121
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC010980.2
chr2
222317242
222318653
-
AC022167.2
chr16
8848105
8860456
+
AC093010.3
chr3
114314501
114329714
-
AF254983.1
chr21
10482738
10605716
+
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
EBLN3P
chr9
37079645
37090928
+
HCG11
chr6
26521709
26527404
+
LINC00662
chr19
27681072
27794005
-
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
OTUD6B-AS1
chr8
91059318
91070583
-
SDCBP2-AS1
chr20
1325405
1378735
+
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.