Entry Detail


General Information

Database ID:exR0256920
RNA Name:hsa-miR-147a
RNA Type:miRNA
Chromosome:chr9
Starnd:-
Coordinate:
Start Site(bp):120244985End Site(bp):120245004
External Links:hsa-miR-147a



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
TWF1
chr12
43793723
43806375
-
GLYR1
chr16
4803203
4847288
-
PLPP6
chr9
4662294
4665258
+
USP37
chr2
218450251
218568351
-
CTSD
chr11
1752755
1764573
-
NUP58
chr13
25301556
25349800
+
JARID2
chr6
15246069
15522042
+
SCARB1
chr12
124776856
124882668
-
MGRN1
chr16
4616493
4690974
+
CRKL
chr22
20917407
20953747
+
SIPA1L3
chr19
37907208
38208369
+
TIMP3
chr22
32801701
32863043
+
SNAI2
chr8
48917598
48921740
-
FAM13A
chr4
88725955
89111398
-
ZNF618
chr9
113876282
114056591
+
SMIM12
chr1
34712737
34859755
-
CCND1
chr11
69641156
69654474
+
FOXK2
chr17
82519713
82644662
+
SLC7A1
chr13
29509414
29595688
-
ATP11A
chr13
112690329
112887168
+
PSME3
chr17
42824385
42843760
+
WIZ
chr19
15419978
15449956
-
PURA
chr5
140107777
140125619
+
STARD7
chr2
96184859
96208825
-
OSBPL9
chr1
51577179
51798427
+
PIK3C2A
chr11
17077730
17207983
-
NKIRAS2
chr17
42011382
42025644
+
LIMD1
chr3
45555394
45686341
+
TNFRSF10B
chr8
23020133
23069031
-
ARHGAP35
chr19
46860997
47005077
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000816
chr17
80521229
80526077
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004951.4
chr7
43951910
44019151
-
AC010442.1
chr5
466124
473098
-
AL355987.2
chr9
136800366
136829466
+
DSCAM-AS1
chr21
40383083
40385358
+
KCNQ1OT1
chr11
2608328
2699994
-
MIR503HG
chrX
134543119
134546642
-
NEAT1
chr11
65422774
65445540
+
POLR2J4
chr7
43940895
44019175
-
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.