Entry Detail


General Information

Database ID:exR0256930
RNA Name:hsa-miR-151a-3p
RNA Type:miRNA
Chromosome:chr8
Starnd:-
Coordinate:
Start Site(bp):140732587End Site(bp):140732607
External Links:hsa-miR-151a-3p



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACP1
chr2
264140
278283
+
PCDHA1
chr5
140786136
141012347
+
PCDHA10
chr5
140855883
141012347
+
PCDHA11
chr5
140868183
141012344
+
PCDHA12
chr5
140875302
141012347
+
PCDHA13
chr5
140882124
141012347
+
PCDHA2
chr5
140794852
141012347
+
PCDHA3
chr5
140801028
141012347
+
PCDHA4
chr5
140806929
141012347
+
PCDHA5
chr5
140821604
141012347
+
PCDHA6
chr5
140827958
141012347
+
PCDHA7
chr5
140834248
141012347
+
PCDHA8
chr5
140841187
141012347
+
PCDHA9
chr5
140847463
141012344
+
PCDHAC1
chr5
140926369
141012344
+
PCDHAC2
chr5
140966470
141012347
+
STRBP
chr9
123109500
123268586
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC044784.1
chr10
8970125
8973468
+
AC104794.2
chr2
10083781
10086101
+
AL160006.1
chr1
110058340
110062555
+
SCARNA9
chr11
93721513
93721865
+
TUG1
chr22
30969245
30979395
+
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.