Entry Detail


General Information

Database ID:exR0257148
RNA Name:hsa-miR-29b-3p
RNA Type:miRNA
Chromosome:chr7
Starnd:-
Coordinate:
Start Site(bp):130877467End Site(bp):130877489
External Links:hsa-miR-29b-3p



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AMER1
chrX
64185117
64205708
-
APH1A
chr1
150265399
150269580
-
APP
chr21
25880550
26171128
-
BACH2
chr6
89926528
90296908
-
BIRC5
chr17
78214186
78225636
+
C1QTNF6
chr22
37180166
37199385
-
CALU
chr7
128739292
128773400
+
CREG1
chr1
167529117
167553805
-
FASN
chr17
82078338
82098294
-
KLHL28
chr14
44924319
45042322
-
KMT5C
chr19
55339853
55348121
+
MDN1
chr6
89642498
89819794
-
NASP
chr1
45583846
45618904
+
NMI
chr2
151270470
151289894
-
PER3
chr1
7784320
7845177
+
PGK1
chrX
77910739
78129295
+
QKI
chr6
163414000
163578592
+
RNF138
chr18
32091874
32131561
+
SH3GLB1
chr1
86704570
86748184
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000018
chr1
15860731
15863309
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC007036.3
chr7
30157531
30159534
+
AC012146.1
chr17
5111468
5115004
+
AC018521.1
chr17
47945424
47981736
+
AL137129.1
chr14
61734138
61776260
+
AL355488.1
chr1
110370154
110373003
+
AL391244.1
chr1
1420245
1422691
+
AP001432.1
chr21
37221419
37237744
+
H19
chr11
1995176
2001470
-
MIR4458HG
chr5
8450701
8486930
+
MIR497HG
chr17
7015818
7019659
-
MIRLET7BHG
chr22
46053869
46113928
+
NEAT1
chr11
65422774
65445540
+
OIP5-AS1
chr15
41283990
41309737
+
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.