Entry Detail


General Information

Database ID:exR0257418
RNA Name:hsa-miR-367-3p
RNA Type:miRNA
Chromosome:chr4
Starnd:-
Coordinate:
Start Site(bp):112647877End Site(bp):112647898
External Links:hsa-miR-367-3p



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
FHL1
chrX
136146702
136211359
+
LRP12
chr8
104489231
104589024
-
RALY
chr20
33993646
34108308
+
THOC2
chrX
123600561
123733056
-
ACTB
chr7
5527148
5563784
-
DCP2
chr5
112976702
113022195
+
PKM
chr15
72199029
72231822
-
METTL7A
chr12
50923472
50932510
+
CCNF
chr16
2429394
2458854
+
ATP6V1A
chr3
113747033
113812056
+
SELENOT
chr3
150602875
150630445
+
HSPA4
chr5
133052013
133106449
+
EML4
chr2
42169353
42332548
+
VIM
chr10
17228241
17237593
+
TRIM13
chr13
49995888
50020481
+
MRS2
chr6
24402908
24426194
+
SCML2
chrX
18239313
18354688
-
CGN
chr1
151510510
151538692
+
NCAPD3
chr11
134150119
134225454
-
ADCY9
chr16
3953387
4116442
-
ZNF451
chr6
57086844
57170305
+
SAR1B
chr5
134601149
134649271
-
CALM2
chr2
47160083
47176921
-
CTNNB1
chr3
41194741
41260096
+
NEK4
chr3
52708444
52770946
-
IGSF8
chr1
160091340
160098943
-
SH3PXD2A
chr10
103594027
103855543
-
RAB9A
chrX
13689128
13710504
+
TUBA1C
chr12
49188736
49274603
+
TMED10
chr14
75131469
75176612
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001005
chr2
53921020
53978078
-
hsa_circ_0001414
chr4
56277780
56284152
+
hsa_circ_0000126
chr1
150997086
150999803
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005394.2
chr19
28435388
28727680
-
AC008040.1
chr3
169939353
169966734
-
AC074117.1
chr2
27356246
27367622
+
AC130650.2
chr16
14150833
14153235
+
DAPK1-IT1
chr9
87553454
87554459
+
LINC01128
chr1
825138
859446
+
MALAT1
chr11
65497688
65506516
+
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
PITPNA-AS1
chr17
1516931
1518096
+
PURPL
chr5
27217714
27496994
+
SNHG5
chr6
85650491
85678932
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.