Entry Detail


General Information

Database ID:exR0258563
RNA Name:hsa-miR-624-3p
RNA Type:miRNA
Chromosome:chr14
Starnd:-
Coordinate:
Start Site(bp):31014669End Site(bp):31014689
External Links:hsa-miR-624-3p



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CBL
chr11
119206298
119313926
+
GPCPD1
chr20
5544439
5611006
-
MDK
chr11
46380756
46383837
+
PTPA
chr9
129110950
129148946
+
SOBP
chr6
107490106
107661306
+
VANGL1
chr1
115641970
115698224
+
WSB2
chr12
118032694
118062430
-
ZBTB5
chr9
37438102
37465450
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000095
chr1
95609446
95616975
+
hsa_circ_0000698
chr16
47531309
47549512
+
hsa_circ_0000552
chr14
71880664
71948928
+
hsa_circ_0001376
chr3
194169185
194175121
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005034.3
chr2
75697583
75697996
+
AC010327.5
chr19
55216660
55221616
+
AC016876.2
chr17
7581964
7584086
-
AL162171.3
chr14
88589231
88592408
+
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
DHRS4-AS1
chr14
23938219
24052555
-
MIR17HG
chr13
91347820
91354579
+
NEAT1
chr11
65422774
65445540
+
SNHG1
chr11
62851984
62855953
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.