Entry Detail


General Information

Database ID:exR0258573
RNA Name:hsa-miR-629-5p
RNA Type:miRNA
Chromosome:chr15
Starnd:-
Coordinate:
Start Site(bp):70079427End Site(bp):70079447
External Links:hsa-miR-629-5p



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
BAZ2A
chr12
56595596
56636816
-
CBX2
chr17
79778148
79787983
+
CBX3
chr7
26201162
26213607
+
COL4A1
chr13
110148963
110307157
-
DENND5B
chr12
31382226
31591136
-
GRB10
chr7
50590063
50793462
-
HDLBP
chr2
241227264
241317061
-
LDLR
chr19
11089462
11133820
+
MCM3
chr6
52264014
52284881
-
MSI1
chr12
120341330
120369164
-
NOLC1
chr10
102152176
102163871
+
PA2G4
chr12
56104537
56113910
+
PHF12
chr17
28905250
28951771
-
PRR12
chr19
49591182
49626439
+
RSU1
chr10
16590611
16817463
-
SH3KBP1
chrX
19533977
19887600
-
SH3PXD2A
chr10
103594027
103855543
-
TULP4
chr6
158232236
158511828
+
UBN2
chr7
139230356
139308236
+
WIPF2
chr17
40219304
40284136
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0001230
chr22
38895404
38897285
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC021078.1
chr5
149494314
149504670
-
NEAT1
chr11
65422774
65445540
+
U62317.3
chr22
50597152
50597599
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.