Entry Detail


General Information

Database ID:exR0258585
RNA Name:hsa-miR-641
RNA Type:miRNA
Chromosome:chr19
Starnd:-
Coordinate:
Start Site(bp):40282603End Site(bp):40282626
External Links:hsa-miR-641



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AIF1L
chr9
131096476
131123152
+
AKT2
chr19
40230317
40285536
-
C19orf47
chr19
40319536
40348527
-
CDKN1A
chr6
36676460
36687339
+
F11R
chr1
160995211
161021343
-
FOXN3
chr14
89124871
89619149
-
GATAD2B
chr1
153789030
153923360
-
GCNT2
chr6
10492223
10629368
+
GNPTAB
chr12
101745499
101830959
-
HMGA2
chr12
65824131
65966295
+
ICE1
chr5
5420664
5490220
+
JPT1
chr17
75135248
75168281
-
LSM14A
chr19
34172504
34229515
+
MED13L
chr12
115953872
116277719
-
PRSS16
chr6
27247701
27256624
+
SETD7
chr4
139495941
139606699
-
SOCS3
chr17
78356778
78360077
-
SYNJ2BP
chr14
70366499
70417090
-
SYNJ2BP-COX16
chr14
70326064
70417074
-
ZDHHC6
chr10
112424428
112446917
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001085
chr2
191765289
191789319
+
hsa_circ_0001168
chr20
47691321
47707559
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC125257.1
chr17
41848518
41851447
-
AC239868.1
chr1
149861271
149862504
+
AL034397.3
chrX
66015461
66020422
+
AL049795.2
chr1
32170733
32176568
+
AL355075.4
chr14
20343048
20343685
-
DLEU2
chr13
49956670
50125720
-
LINC00641
chr14
21200079
21206900
-
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
SNHG1
chr11
62851984
62855953
-
SNHG16
chr17
76557764
76565348
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.