Entry Detail


General Information

Database ID:exR0258668
RNA Name:hsa-miR-671-5p
RNA Type:miRNA
Chromosome:chr7
Starnd:+
Coordinate:
Start Site(bp):151238449End Site(bp):151238471
External Links:hsa-miR-671-5p



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
RCOR1
chr14
102592649
102730561
+
KIAA0232
chr4
6781375
6884170
+
TAF8
chr6
42050513
42087461
+
MAFG
chr17
81918270
81927735
-
DYRK1A
chr21
37365573
37526358
+
MED22
chr9
133338312
133348131
-
KLC1
chr14
103561896
103714249
+
CBX6
chr22
38861422
38872249
-
SAMD4B
chr19
39342396
39385710
+
GTSE1
chr22
46296870
46330810
+
SETD5
chr3
9397615
9479240
+
CREG1
chr1
167529117
167553805
-
IRS2
chr13
109752695
109786583
-
SCAMP3
chr1
155255979
155262430
-
CCDC6
chr10
59788747
59906556
-
BAZ2A
chr12
56595596
56636816
-
WDR82
chr3
52254434
52288020
-
TOMM6
chr6
41787662
41789898
+
FAM219A
chr9
34398184
34458570
-
STAT3
chr17
42313324
42388568
-
UHRF1BP1
chr6
34792015
34883138
+
AL365205.1
chr6
41780349
41790141
+
NACC1
chr19
13116862
13141147
+
SMAD3
chr15
67063763
67195169
+
WDTC1
chr1
27234632
27308636
+
IL1R1
chr2
102064544
102179874
+
PTPRU
chr1
29236516
29326813
+
GLYR1
chr16
4803203
4847288
-
APLP2
chr11
130068147
130144811
+
CHTF8
chr16
69118010
69132578
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC067930.1
chr8
143579636
143580670
+
AC145207.5
chr17
81878425
81881106
-
AL022311.1
chr22
37876148
37895563
+
AL137127.1
chr1
19072110
19075511
-
H19
chr11
1995176
2001470
-
KCNQ1OT1
chr11
2608328
2699994
-
LINC01278
chrX
63222993
63561095
-
MIR29B2CHG
chr1
207801518
207879115
-
NEAT1
chr11
65422774
65445540
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.