Entry Detail


General Information

Database ID:exR0259082
RNA Name:hsa-miR-760
RNA Type:miRNA
Chromosome:chr1
Starnd:+
Coordinate:
Start Site(bp):93846880End Site(bp):93846899
External Links:hsa-miR-760



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABL1
chr9
130713016
130887675
+
ACVR1B
chr12
51951699
51997078
+
ARID3B
chr15
74541177
74598131
+
C6orf89
chr6
36871870
36928964
+
CHTF8
chr16
69118010
69132578
-
DBNDD1
chr16
90004871
90020128
-
DDX54
chr12
113157174
113185479
-
DMWD
chr19
45782947
45792845
-
EFTUD2
chr17
44849948
44899445
-
ITGA5
chr12
54395261
54419266
-
MEF2D
chr1
156463727
156500779
-
PDCD6
chr5
271621
314974
+
PDE8A
chr15
84980440
85139145
+
PDXK
chr21
43719094
43762307
+
RAE1
chr20
57351223
57379211
+
SLC35B2
chr6
44254096
44257890
-
TELO2
chr16
1493344
1510457
+
TSPAN14
chr10
80454166
80533124
+
WSB2
chr12
118032694
118062430
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000458
chr12
124071293
124074996
+
hsa_circ_0000038
chr1
28800065
28802803
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
KCNQ1OT1
chr11
2608328
2699994
-
MALAT1
chr11
65497688
65506516
+
MIR194-2HG
chr11
64889560
64893449
-
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
SNHG1
chr11
62851984
62855953
-
TUG1
chr22
30969245
30979395
+
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.