Entry Detail


General Information

Database ID:exR0259092
RNA Name:hsa-miR-769-5p
RNA Type:miRNA
Chromosome:chr19
Starnd:+
Coordinate:
Start Site(bp):46018961End Site(bp):46018982
External Links:hsa-miR-769-5p



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACVR1B
chr12
51951699
51997078
+
ANGEL1
chr14
76786168
76826246
-
ASB1
chr2
238426742
238452250
+
BMPR2
chr2
202376327
202567751
+
CAPNS1
chr19
36139953
36150353
+
CBFB
chr16
67028984
67101058
+
CLDN11
chr3
170418865
170454733
+
CLN8
chr8
1755778
1801711
+
DBNDD1
chr16
90004871
90020128
-
DCTN4
chr5
150708440
150759109
-
EIF1AD
chr11
65996545
66002176
-
EIF1AX
chrX
20124525
20141838
-
FOXK1
chr7
4682295
4771442
+
LONRF2
chr2
100271875
100322501
-
MDM4
chr1
204516379
204558120
+
MRTO4
chr1
19251805
19260128
+
NUSAP1
chr15
41320794
41381050
+
PLCD3
chr17
45108959
45133354
-
PRKAA1
chr5
40759379
40798374
-
PXN
chr12
120210439
120265771
-
RHPN1
chr8
143368876
143384221
+
RUNX1
chr21
34787801
36004667
-
TFAP4
chr16
4257186
4273075
-
VAT1
chr17
43014607
43025123
-
YPEL5
chr2
30146941
30160533
+
ZDHHC9
chrX
129803288
129843909
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC245033.4
chr15
82533175
82540008
-
LINC00324
chr17
8220642
8224043
-
MALAT1
chr11
65497688
65506516
+
SNHG1
chr11
62851984
62855953
-
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.