Entry Detail


General Information

Database ID:exR0259193
RNA Name:hsa-miR-92a-3p
RNA Type:miRNA
Chromosome:chrX
Starnd:-
Coordinate:
Start Site(bp):134169544End Site(bp):134169565
External Links:hsa-miR-92a-3p



Disease Information

Disease Name:Obesity
Disease Category:Other Diseases
MeSH ID:D009765
Type:Diseases Category/Nutritional and Metabolic Diseases
Alias:Appetite Depressants//Body Weight//Diet, Reducing//Skinfold Thickness//Lipectomy//Anti-Obesity Agents//Bariatrics



Expression Detail

GEO ID:GSE125494
Description:Adipocyte-Derived Exosomal microRNAs in subject serum samples
Experimental Design:Disease vs Control
Case Disease Type:Obesity
Case Disease SubType:NA
Case Sample:Obesity
Control Sample:Control
Number of Case:8
Number of Control:3
Number of Samples:11





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
MAZ
chr16
29806106
29811164
+
RPS8
chr1
44775251
44778779
+
ESRP1
chr8
94641074
94707466
+
PTPRZ1
chr7
121873089
122062036
+
YIPF3
chr6
43511832
43516985
-
SEC63
chr6
107867756
107958208
-
NPM1
chr5
171387116
171411137
+
USP21
chr1
161159450
161165723
+
ZNF330
chr4
141220887
141234697
+
HBE1
chr11
5268345
5505652
-
EHMT2
chr6
31879759
31897687
-
PITPNA
chr17
1517718
1562792
-
RBBP5
chr1
205086142
205122015
-
PNKD
chr2
218270392
218346793
+
SMC1A
chrX
53374149
53422728
-
RWDD1
chr6
116571409
116597675
+
GLCE
chr15
69160584
69272217
+
CEP89
chr19
32875925
32971991
-
PPP3CB
chr10
73436428
73496024
-
HMGB1
chr13
30456704
30617597
-
KLF4
chr9
107484852
107490482
-
MRPS16
chr10
73248843
73252693
-
TCP1
chr6
159778498
159789703
-
EZR
chr6
158765741
158819368
-
PSMB8
chr6
32840717
32844679
-
RPL17-C18orf32
chr18
49481681
49492479
-
OGFOD1
chr16
56451521
56479104
+
MCM3
chr6
52264014
52284881
-
EIF4G2
chr11
10797050
10808940
-
RPL13A
chr19
49487554
49492308
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001005
chr2
53921020
53978078
-
hsa_circ_0001414
chr4
56277780
56284152
+
hsa_circ_0000126
chr1
150997086
150999803
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005394.2
chr19
28435388
28727680
-
AC074117.1
chr2
27356246
27367622
+
AC130650.2
chr16
14150833
14153235
+
DAPK1-IT1
chr9
87553454
87554459
+
LINC01128
chr1
825138
859446
+
MALAT1
chr11
65497688
65506516
+
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
PITPNA-AS1
chr17
1516931
1518096
+
PURPL
chr5
27217714
27496994
+
SNHG5
chr6
85650491
85678932
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE125494
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:To isolate exosomes, we used the serum from lean and obese subejcts and used ExoQuick-TC precipitation solution, according to ExoQuick-TC protocol. We also used StemCell Technologies Magnetic Isolation Technique to isolate FABP4+ specific exosomes.
RNA Extract protocol:Total RNA was isolated following mirVana's total RNA Isolation kit.
RNA library preparation protocol:biotin We used Affymetrix FlashTag Biotin HSR RNA Labeling Kit to label 1000 ng of cRNA from each sample



Reference

PMID:31331347
Title:Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Author:Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ
Journal:J Transl Med. 2019 Jul 22;17(1):232.
Description:We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.