Entry Detail



General Information

Database ID:exR0266833
RNA Name:hsa-miR-19b-3p
RNA Type:miRNA
Chromosome:chr13
Starnd:+
Coordinate:
Start Site(bp):91351245End Site(bp):91351267
External Links:hsa-miR-19b-3p



Disease Information

Disease Name:Cystic Fibrosis
Disease Category:Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:D003550
Type:Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas



Expression Detail

GEO ID:GSE135119
Description:Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis
Experimental Design:Disease vs Control
Case Disease Type:Cystic Fibrosis
Case Disease SubType:NA
Case Sample:Cystic Fibrosis
Control Sample:Healthy
Number of Case:5
Number of Control:5
Number of Samples:10





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
BCL7A
chr12
122019422
122062044
+
UBA1
chrX
47190861
47215128
+
RPS23
chr5
82273320
82278396
-
ALDH3A2
chr17
19648136
19685760
+
MEF2D
chr1
156463727
156500779
-
TBC1D25
chrX
48539714
48562609
+
ANAPC16
chr10
72216000
72235860
+
PYGB
chr20
25248085
25298012
+
CASP2
chr7
143288215
143307696
+
TUB
chr11
8019244
8106112
+
SRSF6
chr20
43457893
43466046
+
CAMTA1
chr1
6785454
7769706
+
PMPCB
chr7
103297435
103329511
+
RFX1
chr19
13961530
14007039
-
BTBD7
chr14
93237550
93333092
-
ZNF397
chr18
35241030
35267133
+
F13A1
chr6
6144084
6321013
-
DNAJC16
chr1
15526813
15592379
+
HOMER1
chr5
79372636
79514134
-
REV1
chr2
99400475
99490035
-
RAB18
chr10
27504174
27542237
+
TBL1X
chrX
9463295
9741037
+
MTREX
chr5
55307989
55425579
+
PTPN21
chr14
88465778
88555007
-
EIF4A2
chr3
186783205
186789897
+
PATL1
chr11
59636716
59669037
-
ST3GAL5
chr2
85837120
85905199
-
USP14
chr18
158383
214629
+
CLDN6
chr16
3014712
3020071
-
COPB1
chr11
14443440
14500027
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001454
chr4
154524454
154533552
+
hsa_circ_0001186
chr21
35475133
35475818
+
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0001605
chr6
42903447
42905047
+
hsa_circ_0000155
chr1
168007608
168014465
+
hsa_circ_0001495
chr5
68470703
68471364
+
hsa_circ_0000943
chr19
47421744
47440665
+
hsa_circ_0001164
chr20
45891031
45923523
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005394.2
chr19
28435388
28727680
-
AC010997.3
chr10
75279726
75401246
-
AC011498.2
chr19
4447304
4448217
+
AC011503.2
chr19
23927788
23929287
+
AC021078.1
chr5
149494314
149504670
-
AC135050.6
chr16
31122235
31124064
+
AL049840.4
chr14
103694516
103695050
-
AL158206.1
chr9
19453209
19455173
+
AL158825.2
chr9
75009828
75016036
-
H19
chr11
1995176
2001470
-
HAGLR
chr2
176164051
176188958
-
LAMTOR5-AS1
chr1
110347116
110443817
+
LINC00667
chr18
5237826
5290608
+
MCM3AP-AS1
chr21
46229196
46259390
+
NEAT1
chr11
65422774
65445540
+
SNHG20
chr17
77086716
77099902
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE135119
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL19117
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2346
Sample treatment protocol:NA
RNA Extract protocol:Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit.
RNA library preparation protocol:Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.



Reference

PMID:31664087
Title:Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis
Author:Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H
Journal:Sci Rep. 2019 Oct 29;9(1):15483.
Description:we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.