exRNAdisease

Entry Detail

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General Information

Database ID: exR0267981 RNA Name: hsa-miR-520e-3p RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 53675764 End Site(bp): 53675784 External Links: hsa-miR-520e-3p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SLC16A14 chr2 230034982 230068993 - ADAR chr1 154582057 154628013 - TRIB1 chr8 125430358 125438403 + ARL4A chr7 12686856 12690958 + EIF5A2 chr3 170888418 170908644 - ATXN1 chr6 16299112 16761491 - PHC3 chr3 170086732 170181749 - DIP2A chr21 46458891 46570015 + MLLT1 chr19 6210381 6279975 - SBF1 chr22 50445000 50475035 - CLIP4 chr2 29097705 29189643 + JPT1 chr17 75135248 75168281 - SEMA3C chr7 80742538 80922359 - USP24 chr1 55066359 55215364 - CHD9 chr16 53055033 53329150 + C9orf40 chr9 74946583 74952912 - CUL1 chr7 148697914 148801110 + RGMA chr15 93035273 93089204 - CAMK2N1 chr1 20482391 20486210 - PTP4A1 chr6 63521746 63583436 + CLCN6 chr1 11806096 11848079 + TRIM37 chr17 58982638 59106921 - MAGI3 chr1 113390515 113685923 + RAB31 chr18 9708275 9862551 + OCRL chrX 129539849 129592561 + APP chr21 25880550 26171128 - SIRPA chr20 1894167 1940592 + CCDC93 chr2 117915478 118014133 - KIAA1522 chr1 32741830 32774970 + SEC16A chr9 136440096 136483759 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL049840.4 chr14 103694516 103695050 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.