exRNAdisease

Entry Detail

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General Information

Database ID: exR0268798 RNA Name: hsa-miR-873-5p RNA Type: miRNA Chromosome: chr9 Starnd: - Coordinate: Start Site(bp): 28888925 End Site(bp): 28888945 External Links: hsa-miR-873-5p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CACUL1 chr10 118674167 118755249 - ICAM1 chr19 10271093 10286615 + IDS chrX 149476988 149521096 - NUDT3 chr6 34279679 34392669 - EPHA4 chr2 221418027 221574202 - TRIOBP chr22 37697048 37776556 + BCL2L11 chr2 111119378 111168445 + SEPHS2 chr16 30443631 30445874 - PFKFB3 chr10 6144934 6254644 + PSD3 chr8 18527303 19084730 - PRDM15 chr21 41798225 41879482 - DLG3 chrX 70444835 70505490 + ORAI1 chr12 121626550 121642677 + LMBR1 chr7 156668946 156893216 - TRIO chr5 14143342 14532128 + OTUB1 chr11 63985853 64001811 + HDGF chr1 156742109 156766925 - FAM222B chr17 28755978 28855232 - TBX3 chr12 114670255 114684175 - BCL9L chr11 118893875 118925608 - CTTNBP2NL chr1 112396214 112463456 + CENPX chr17 82018702 82024107 - SMG5 chr1 156249224 156282825 - PLAGL2 chr20 32192504 32207743 - BICRA chr19 47608196 47703277 + CSNK1E chr22 38290691 38318084 - TMEM179B chr11 62787402 62790400 + DBNDD1 chr16 90004871 90020128 - ZXDB chrX 57591652 57597545 + APPL2 chr12 105173297 105236203 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0000987 chr2 30748452 30756180 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC002116.1 chr19 36008638 36014235 - AC079781.5 chr7 97851688 97972985 - AC084809.2 chr17 32905662 32906584 + AC239868.1 chr1 149861271 149862504 + AC245033.4 chr15 82533175 82540008 - AL022311.1 chr22 37876148 37895563 + AL049543.1 chr6 28587378 28591747 + AL355987.2 chr9 136800366 136829466 + GAS5 chr1 173858559 173868882 - LINC01535 chr19 37251885 37265535 + MALAT1 chr11 65497688 65506516 + MIR4435-2HG chr2 111006015 111523376 - MIR503HG chrX 134543119 134546642 - NEAT1 chr11 65422774 65445540 + SNHG15 chr7 44983023 44986961 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.