exRNAdisease

Entry Detail

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General Information

Database ID: exR0268870 RNA Name: hsa-miR-1-3p RNA Type: miRNA Chromosome: chr18 Starnd: - Coordinate: Start Site(bp): 21829015 End Site(bp): 21829036 External Links: hsa-miR-1-3p

Disease Information

Disease Name: Chronic Thromboembolic Pulmonary Hypertension Disease Category: Respiratory Tract Diseases MeSH ID: D006976 Type: Diseases Category/Respiratory Tract Diseases Alias: Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID: GSE138107 Description: Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA Experimental Design: Disease vs Control Case Disease Type: Chronic Thromboembolic Pulmonary Hypertension Case Disease SubType: NA Case Sample: Chronic Thromboembolic Pulmonary Hypertension Control Sample: Control Number of Case: 3 Number of Control: 3 Number of Samples: 6

Regulatory Relationship

mRNA targets: NA miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000816 chr17 80521229 80526077 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005332.7 chr17 68188547 68189165 + AC145207.5 chr17 81878425 81881106 - LINC00641 chr14 21200079 21206900 - MALAT1 chr11 65497688 65506516 + MIR4435-2HG chr2 111006015 111523376 - NEAT1 chr11 65422774 65445540 + RMRP chr9 35657751 35658018 - Display:

Experiment Detail

GEO ID: GSE138107 Sample Source: Blood Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 3 Num of detected RNAs of this Type: 359 Sample treatment protocol: Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis. RNA Extract protocol: total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum. RNA library preparation protocol: SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID: 31671920 Title: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Author: Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C Journal: Biomolecules. 2019 Oct 29;9(11). pii: E666. Description: We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.