exRNAdisease

Entry Detail

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General Information

Database ID: exR0268902 RNA Name: hsa-miR-140-5p RNA Type: miRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 69933103 End Site(bp): 69933124 External Links: hsa-miR-140-5p

Disease Information

Disease Name: Chronic Thromboembolic Pulmonary Hypertension Disease Category: Respiratory Tract Diseases MeSH ID: D006976 Type: Diseases Category/Respiratory Tract Diseases Alias: Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID: GSE138107 Description: Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA Experimental Design: Disease vs Control Case Disease Type: Chronic Thromboembolic Pulmonary Hypertension Case Disease SubType: NA Case Sample: Chronic Thromboembolic Pulmonary Hypertension Control Sample: Control Number of Case: 3 Number of Control: 3 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ARIH1 chr15 72474330 72602987 + BTBD7 chr14 93237550 93333092 - C15orf41 chr15 36579626 36810248 + CLPTM1 chr19 44954585 44993341 + COL4A2 chr13 110305812 110513209 + ITPRIPL2 chr16 19113932 19121629 + NME4 chr16 396725 410367 + POLR3G chr5 90471748 90514557 + SCRN1 chr7 29920104 29990289 - SLC6A6 chr3 14402576 14489349 + SRP14 chr15 40035690 40039181 - TMEM181 chr6 158536436 158635428 + TNRC6B chr22 40044817 40335808 + TRIO chr5 14143342 14532128 + ZNF800 chr7 127346790 127431924 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000712 chr16 68208276 68225678 + hsa_circ_0001699 chr7 40027197 40041630 + hsa_circ_0001472 chr5 36953719 36976504 + hsa_circ_0000032 chr1 25666964 25669564 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL162258.1 chr1 153626332 153634340 - DHRS4-AS1 chr14 23938219 24052555 - H19 chr11 1995176 2001470 - KCNQ1OT1 chr11 2608328 2699994 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + SNHG1 chr11 62851984 62855953 - SNHG16 chr17 76557764 76565348 + SNHG20 chr17 77086716 77099902 + TDRKH-AS1 chr1 151790804 151794402 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE138107 Sample Source: Blood Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 3 Num of detected RNAs of this Type: 359 Sample treatment protocol: Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis. RNA Extract protocol: total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum. RNA library preparation protocol: SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID: 31671920 Title: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Author: Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C Journal: Biomolecules. 2019 Oct 29;9(11). pii: E666. Description: We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.