exRNAdisease

Entry Detail

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General Information

Database ID: exR0268962 RNA Name: hsa-miR-214-3p RNA Type: miRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 172138816 End Site(bp): 172138837 External Links: hsa-miR-214-3p

Disease Information

Disease Name: Chronic Thromboembolic Pulmonary Hypertension Disease Category: Respiratory Tract Diseases MeSH ID: D006976 Type: Diseases Category/Respiratory Tract Diseases Alias: Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID: GSE138107 Description: Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA Experimental Design: Disease vs Control Case Disease Type: Chronic Thromboembolic Pulmonary Hypertension Case Disease SubType: NA Case Sample: Chronic Thromboembolic Pulmonary Hypertension Control Sample: Control Number of Case: 3 Number of Control: 3 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MTMR12 chr5 32226994 32312987 - AP3M1 chr10 74120255 74151063 - AMER1 chrX 64185117 64205708 - GDI1 chrX 154436913 154443467 + RPUSD1 chr16 784974 788397 - SMG5 chr1 156249224 156282825 - DHX36 chr3 154272546 154324487 - PIP5K1C chr19 3630183 3700479 - C19orf47 chr19 40319536 40348527 - MTMR3 chr22 29883155 30030866 + ABHD2 chr15 89087459 89202355 + MAPKAPK2 chr1 206684944 206734283 + RHPN1 chr8 143368876 143384221 + HDLBP chr2 241227264 241317061 - ARHGAP35 chr19 46860997 47005077 + YWHAB chr20 44885702 44908532 + WDR5 chr9 134135365 134159968 + RPS6KA1 chr1 26529761 26575030 + JPT1 chr17 75135248 75168281 - SEC61A1 chr3 128051641 128071683 + TMEM161B chr5 88189633 88269476 - NECTIN1 chr11 119623408 119729200 - SOX11 chr2 5692384 5701385 + MYH9 chr22 36281277 36388067 - RAB15 chr14 64945814 64973226 - PLAGL2 chr20 32192504 32207743 - TGIF2 chr20 36573488 36593950 + NRIP1 chr21 14961235 15065936 - LYSMD2 chr15 51723011 51751585 - KMT2D chr12 49018975 49059774 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008040.1 chr3 169939353 169966734 - AC010442.1 chr5 466124 473098 - AC016876.2 chr17 7581964 7584086 - AC068790.9 chr12 124085761 124088598 + AC109460.3 chr16 28974804 28990775 + ADAMTSL4-AS1 chr1 150560202 150574552 - AL031282.2 chr1 1702736 1737688 - AL160006.1 chr1 110058340 110062555 + EPB41L4A-AS1 chr5 112160526 112164818 + FGD5-AS1 chr3 14920347 14948424 - LINC00665 chr19 36313067 36331770 - LINC01535 chr19 37251885 37265535 + MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + POLR2J4 chr7 43940895 44019175 - SNHG16 chr17 76557764 76565348 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE138107 Sample Source: Blood Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 3 Num of detected RNAs of this Type: 359 Sample treatment protocol: Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis. RNA Extract protocol: total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum. RNA library preparation protocol: SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID: 31671920 Title: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Author: Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C Journal: Biomolecules. 2019 Oct 29;9(11). pii: E666. Description: We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.