Entry Detail


General Information

Database ID:exR0268963
RNA Name:hsa-miR-22-3p
RNA Type:miRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):1713914End Site(bp):1713935
External Links:hsa-miR-22-3p



Disease Information

Disease Name:Chronic Thromboembolic Pulmonary Hypertension
Disease Category:Respiratory Tract Diseases
MeSH ID:D006976
Type:Diseases Category/Respiratory Tract Diseases
Alias:Hypertension, Pulmonary//Pulmonary Hypertension



Expression Detail

GEO ID:GSE138107
Description:Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:Disease vs Control
Case Disease Type:Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:NA
Case Sample:Chronic Thromboembolic Pulmonary Hypertension
Control Sample:Control
Number of Case:3
Number of Control:3
Number of Samples:6





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CCDC97
chr19
41310172
41324873
+
AP1S1
chr7
101154456
101161596
+
RCOR1
chr14
102592649
102730561
+
RAB11FIP4
chr17
31391675
31538211
+
PPIF
chr10
79347469
79355334
+
FBXL19
chr16
30923055
30948783
+
FNBP4
chr11
47716494
47767443
-
DCP1A
chr3
53283429
53347586
-
GDAP1
chr8
74321130
74488872
+
WSB2
chr12
118032694
118062430
-
ITGA5
chr12
54395261
54419266
-
IRS2
chr13
109752695
109786583
-
FOXP1
chr3
70952817
71583993
-
TMEM179B
chr11
62787402
62790400
+
ETS1
chr11
128458761
128587558
-
ATP2C1
chr3
130850595
131016712
+
ZNF740
chr12
53180704
53195142
+
CACUL1
chr10
118674167
118755249
-
ATP6V0B
chr1
43974487
43978295
+
ACLY
chr17
41866917
41930542
-
CLASP1
chr2
121337776
121649587
-
PRLR
chr5
35048756
35230487
-
PDPR
chr16
70113626
70162537
+
WWC2
chr4
183099257
183320777
+
TAGLN
chr11
117199370
117207464
+
BCL9
chr1
147541501
147626216
+
GLIS2
chr16
4314761
4339597
+
GBF1
chr10
102245532
102382899
+
PDSS1
chr10
26697701
26746798
+
RANBP2
chr2
108719482
108785809
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001699
chr7
40027197
40041630
+
hsa_circ_0001414
chr4
56277780
56284152
+
hsa_circ_0000733
chr17
1561546
1562030
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC021078.1
chr5
149494314
149504670
-
AL360012.1
chr1
28648600
28648730
+
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
SNHG16
chr17
76557764
76565348
+
Display:



Experiment Detail

GEO ID:GSE138107
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:3
Num of detected RNAs of this Type:359
Sample treatment protocol:Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)



Reference

PMID:31671920
Title:Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.