exRNAdisease

Entry Detail

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General Information

Database ID: exR0268982 RNA Name: hsa-miR-27a-3p RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 13836447 End Site(bp): 13836467 External Links: hsa-miR-27a-3p

Disease Information

Disease Name: Chronic Thromboembolic Pulmonary Hypertension Disease Category: Respiratory Tract Diseases MeSH ID: D006976 Type: Diseases Category/Respiratory Tract Diseases Alias: Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID: GSE138107 Description: Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA Experimental Design: Disease vs Control Case Disease Type: Chronic Thromboembolic Pulmonary Hypertension Case Disease SubType: NA Case Sample: Chronic Thromboembolic Pulmonary Hypertension Control Sample: Control Number of Case: 3 Number of Control: 3 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand IGF2BP3 chr7 23310209 23470491 - SOX11 chr2 5692384 5701385 + AEN chr15 88621337 88632281 + SUCO chr1 172532349 172611833 + ALDH3A2 chr17 19648136 19685760 + CD2AP chr6 47477789 47627263 + TTYH3 chr7 2631986 2664802 + C1orf116 chr1 207018522 207032756 - GLTP chr12 109850945 109880541 - PAX9 chr14 36657568 36679362 + TMEM30A chr6 75252924 75284948 - NUAK1 chr12 106063340 106140033 - LGALS8 chr1 236518000 236552981 + ACER3 chr11 76860867 77026797 + NEK2 chr1 211658657 211675630 - CDR2 chr16 22345936 22437165 - B4GALT3 chr1 161171310 161177968 - JRK chr8 142657460 142681968 - KCNK1 chr1 233614106 233672514 + ACLY chr17 41866917 41930542 - TMX4 chr20 7977346 8019805 - PPP1CC chr12 110719680 110742939 - KPNA6 chr1 32108056 32176563 + HTT chr4 3041422 3243960 + NF1 chr17 31094927 31382116 + ETNK1 chr12 22625075 22690665 + ZBTB34 chr9 126860665 126885878 + CANX chr5 179678628 179731641 + PAK1 chr11 77321707 77474635 - GIPC1 chr19 14477760 14496149 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0001247 chr22 46125304 46136418 + hsa_circ_0000942 chr19 46020920 46021352 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010980.2 chr2 222317242 222318653 - AC021092.1 chr19 44103007 44113183 - AC022150.4 chr19 52650437 52653284 - AC093010.3 chr3 114314501 114329714 - AL050341.2 chr1 40256427 40257967 - KCNQ1OT1 chr11 2608328 2699994 - LINC01089 chr12 121795267 121803906 - LINC02381 chr12 54126082 54147485 + NEAT1 chr11 65422774 65445540 + SDCBP2-AS1 chr20 1325405 1378735 + SNHG22 chr18 49814023 49851059 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE138107 Sample Source: Blood Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 3 Num of detected RNAs of this Type: 359 Sample treatment protocol: Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis. RNA Extract protocol: total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum. RNA library preparation protocol: SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID: 31671920 Title: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Author: Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C Journal: Biomolecules. 2019 Oct 29;9(11). pii: E666. Description: We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.