Entry Detail


General Information

Database ID:exR0269012
RNA Name:hsa-miR-338-3p
RNA Type:miRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):81125887End Site(bp):81125908
External Links:hsa-miR-338-3p



Disease Information

Disease Name:Chronic Thromboembolic Pulmonary Hypertension
Disease Category:Respiratory Tract Diseases
MeSH ID:D006976
Type:Diseases Category/Respiratory Tract Diseases
Alias:Hypertension, Pulmonary//Pulmonary Hypertension



Expression Detail

GEO ID:GSE138107
Description:Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:Disease vs Control
Case Disease Type:Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:NA
Case Sample:Chronic Thromboembolic Pulmonary Hypertension
Control Sample:Control
Number of Case:3
Number of Control:3
Number of Samples:6





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ADCY9
chr16
3953387
4116442
-
ARPC1B
chr7
99374249
99394816
+
CALU
chr7
128739292
128773400
+
CDT1
chr16
88803789
88809258
+
ENSA
chr1
150600851
150629612
-
ERG28
chr14
75649791
75660876
-
GTSE1
chr22
46296870
46330810
+
KDSR
chr18
63327726
63367228
-
NONO
chrX
71283192
71301168
+
PALLD
chr4
168497052
168928457
+
PURB
chr7
44876299
44885530
-
RAB14
chr9
121178133
121223014
-
TANC2
chr17
63009556
63427699
+
TRIM33
chr1
114392790
114511203
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001025
chr2
69565029
69565697
-
hsa_circ_0000284
chr11
33307958
33309057
+
hsa_circ_0001085
chr2
191765289
191789319
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC008738.7
chr19
33207129
33207639
+
AC109460.3
chr16
28974804
28990775
+
KCNQ1OT1
chr11
2608328
2699994
-
LINC00943
chr12
126723412
126749027
+
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
OIP5-AS1
chr15
41283990
41309737
+
SDCBP2-AS1
chr20
1325405
1378735
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE138107
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:3
Num of detected RNAs of this Type:359
Sample treatment protocol:Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)



Reference

PMID:31671920
Title:Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.