Entry Detail


General Information

Database ID:exR0269014
RNA Name:hsa-miR-339-5p
RNA Type:miRNA
Chromosome:chr7
Starnd:-
Coordinate:
Start Site(bp):1022990End Site(bp):1023012
External Links:hsa-miR-339-5p



Disease Information

Disease Name:Chronic Thromboembolic Pulmonary Hypertension
Disease Category:Respiratory Tract Diseases
MeSH ID:D006976
Type:Diseases Category/Respiratory Tract Diseases
Alias:Hypertension, Pulmonary//Pulmonary Hypertension



Expression Detail

GEO ID:GSE138107
Description:Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:Disease vs Control
Case Disease Type:Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:NA
Case Sample:Chronic Thromboembolic Pulmonary Hypertension
Control Sample:Control
Number of Case:3
Number of Control:3
Number of Samples:6





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABL2
chr1
179099330
179229684
-
ARHGDIA
chr17
81867721
81871378
-
ATXN7
chr3
63864557
64003462
+
EDEM1
chr3
5187646
5219958
+
FEM1A
chr19
4791734
4801273
+
FOXP1
chr3
70952817
71583993
-
G3BP2
chr4
75642782
75724525
-
MMD
chr17
55392622
55421924
-
NCOA6
chr20
34689097
34825651
-
NUSAP1
chr15
41320794
41381050
+
PRDM15
chr21
41798225
41879482
-
PTPA
chr9
129110950
129148946
+
SLC44A1
chr9
105244622
105439171
+
STAT3
chr17
42313324
42388568
-
VCP
chr9
35056064
35072627
-
WDR4
chr21
42843094
42879568
-
ZNF689
chr16
30602558
30624012
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000120
chr1
117944807
118009049
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004069.1
chr4
105137280
105140619
-
AC145207.5
chr17
81878425
81881106
-
GAS5
chr1
173858559
173868882
-
H19
chr11
1995176
2001470
-
KCNQ1OT1
chr11
2608328
2699994
-
LINC01578
chr15
92819540
92899701
+
NEAT1
chr11
65422774
65445540
+
Display:



Experiment Detail

GEO ID:GSE138107
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:3
Num of detected RNAs of this Type:359
Sample treatment protocol:Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)



Reference

PMID:31671920
Title:Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.