exRNAdisease

Entry Detail

---



General Information

Database ID: exR0269015 RNA Name: hsa-miR-33a-5p RNA Type: miRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 41900949 End Site(bp): 41900969 External Links: hsa-miR-33a-5p

Disease Information

Disease Name: Chronic Thromboembolic Pulmonary Hypertension Disease Category: Respiratory Tract Diseases MeSH ID: D006976 Type: Diseases Category/Respiratory Tract Diseases Alias: Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID: GSE138107 Description: Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA Experimental Design: Disease vs Control Case Disease Type: Chronic Thromboembolic Pulmonary Hypertension Case Disease SubType: NA Case Sample: Chronic Thromboembolic Pulmonary Hypertension Control Sample: Control Number of Case: 3 Number of Control: 3 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RBM33 chr7 155644451 155781485 + ARCN1 chr11 118572390 118603033 + CROT chr7 87345681 87399795 + PIM1 chr6 37170152 37175428 + BRIP1 chr17 61679139 61863528 - RAB11FIP2 chr10 118004916 118046941 - ECHDC1 chr6 127288712 127343609 - NFAT5 chr16 69565094 69704666 + ZBTB34 chr9 126860665 126885878 + EIF5A2 chr3 170888418 170908644 - XRN1 chr3 142306607 142448062 - WDFY3 chr4 84669610 84966391 - CERK chr22 46684410 46738252 - IGF1R chr15 98648539 98964530 + MYO19 chr17 36495633 36543435 - E2F3 chr6 20401879 20493714 + AFF4 chr5 132875395 132963634 - DDX5 chr17 64498254 64508199 - RCAN1 chr21 34513142 34615113 - GLCCI1 chr7 7968796 8094272 + ROBO1 chr3 78597239 79767998 - RNF11 chr1 51236273 51273447 + AFF3 chr2 99545419 100192428 - ZDHHC9 chrX 129803288 129843909 - ADCY9 chr16 3953387 4116442 - ZFYVE16 chr5 80408013 80483379 + ZNF148 chr3 125225561 125375354 - MAPK1IP1L chr14 55051647 55070194 + CREM chr10 35126791 35212958 + KPNA4 chr3 160495007 160565571 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001349 chr3 152132729 152150709 + hsa_circ_0000642 chr15 80390757 80415142 + hsa_circ_0000643 chr15 80412669 80415142 + hsa_circ_0000284 chr11 33307958 33309057 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC023509.1 chr12 53441741 53467528 + DANCR chr4 52712404 52720351 + FGD5-AS1 chr3 14920347 14948424 - MCF2L-AS1 chr13 112967484 112968824 - NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: GSE138107 Sample Source: Blood Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 3 Num of detected RNAs of this Type: 359 Sample treatment protocol: Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis. RNA Extract protocol: total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum. RNA library preparation protocol: SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID: 31671920 Title: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Author: Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C Journal: Biomolecules. 2019 Oct 29;9(11). pii: E666. Description: We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.