Entry Detail


General Information

Database ID:exR0269020
RNA Name:hsa-miR-345-5p
RNA Type:miRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):100307876End Site(bp):100307897
External Links:hsa-miR-345-5p



Disease Information

Disease Name:Chronic Thromboembolic Pulmonary Hypertension
Disease Category:Respiratory Tract Diseases
MeSH ID:D006976
Type:Diseases Category/Respiratory Tract Diseases
Alias:Hypertension, Pulmonary//Pulmonary Hypertension



Expression Detail

GEO ID:GSE138107
Description:Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:Disease vs Control
Case Disease Type:Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:NA
Case Sample:Chronic Thromboembolic Pulmonary Hypertension
Control Sample:Control
Number of Case:3
Number of Control:3
Number of Samples:6





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC011455.2
chr19
38915404
38949855
-
CNBP
chr3
129169484
129183922
-
FAM222B
chr17
28755978
28855232
-
GCNT4
chr5
75025346
75052558
-
GPD2
chr2
156435290
156613735
+
HEG1
chr3
124965710
125055997
-
IGF2BP1
chr17
48997385
49056145
+
LCLAT1
chr2
30447226
30644225
+
MAP3K14
chr17
45263119
45317029
-
MAPK1
chr22
21754500
21867680
-
RCOR1
chr14
102592649
102730561
+
RIPOR1
chr16
67518418
67546788
+
SARS2
chr19
38915266
38930896
-
SPTBN2
chr11
66685248
66729226
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001867
chr9
86294689
86297981
-
hsa_circ_0001866
chr9
86293355
86297981
-
hsa_circ_0001392
chr4
3088665
3109150
+
hsa_circ_0001387
chr4
1902352
1936989
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC079781.5
chr7
97851688
97972985
-
GAS5
chr1
173858559
173868882
-
KCNQ1OT1
chr11
2608328
2699994
-
LINC01772
chr1
16460948
16468481
+
NEAT1
chr11
65422774
65445540
+
SNHG15
chr7
44983023
44986961
-
Display:



Experiment Detail

GEO ID:GSE138107
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:3
Num of detected RNAs of this Type:359
Sample treatment protocol:Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)



Reference

PMID:31671920
Title:Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.