exRNAdisease

General Information

Database ID:

exR0269043

RNA Name:

hsa-miR-423-5p

RNA Type:

miRNA

Chromosome:

chr17

Starnd:

Coordinate:

Start Site(bp):

30117095

End Site(bp):

30117117

External Links:

Disease Information

Disease Name:	Chronic Thromboembolic Pulmonary Hypertension
Disease Category:	Respiratory Tract Diseases
MeSH ID:	D006976
Type:	Diseases Category/Respiratory Tract Diseases
Alias:	Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID:	GSE138107
Description:	Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:	Disease vs Control
Case Disease Type:	Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:	NA
Case Sample:	Chronic Thromboembolic Pulmonary Hypertension
Control Sample:	Control
Number of Case:	3
Number of Control:	3
Number of Samples:	6

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
DCAF7	chr17	63550477	63594279	+
PGAM1	chr10	97426191	97433444	+
MINK1	chr17	4833340	4898061	+
PSME3	chr17	42824385	42843760	+
LIMD2	chr17	63695888	63701172	-
SYVN1	chr11	65121780	65134533	-
KLC2	chr11	66257294	66267860	+
MYBL2	chr20	43667019	43716495	+
DLGAP4	chr20	36306336	36528637	+
CAPN15	chr16	527712	554636	+
MAPKBP1	chr15	41774434	41827855	+
PAK2	chr3	196739857	196832647	+
ACTN4	chr19	38647649	38731589	+
C1QTNF6	chr22	37180166	37199385	-
MAPK8IP2	chr22	50600793	50613981	+
BCORL1	chrX	129981107	130058083	+
FAM83H	chr8	143723933	143738234	-
WDR45B	chr17	82614562	82648553	-
CDCA7	chr2	173354820	173368997	+
PRR12	chr19	49591182	49626439	+
CHP1	chr15	41230839	41281887	+
TNFAIP3	chr6	137867214	137883312	+
IL2RB	chr22	37125843	37175054	-
RAB8A	chr19	16111889	16134234	+
HNRNPA2B1	chr7	26173057	26201529	-
ATN1	chr12	6924463	6942321	+
EIF5AL1	chr10	79512601	79516440	+
IGF2BP1	chr17	48997385	49056145	+
PPDPF	chr20	63520765	63522206	+
CTSD	chr11	1752755	1764573	-

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000540	chr14	55799534	55821940	+
hsa_circ_0001472	chr5	36953719	36976504	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC009133.5	chr16	29808679	29812227	+
AC016876.2	chr17	7581964	7584086	-
AC021078.1	chr5	149494314	149504670	-
AL356488.2	chr1	109100193	109100619	+
H19	chr11	1995176	2001470	-
KCNQ1OT1	chr11	2608328	2699994	-
MIR663AHG	chr20	26167817	26251546	-
MIRLET7BHG	chr22	46053869	46113928	+
NEAT1	chr11	65422774	65445540	+
STAG3L5P-PVRIG2P-PILRB	chr7	100336104	100367831	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE138107
Sample Source:	Blood
Source Fraction:	Exosome
Platform:	GPL18573
Method:	NGS
Num of detected RNA Type:	3
Num of detected RNAs of this Type:	359
Sample treatment protocol:	Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:	total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:	SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID:	31671920
Title:	Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:	Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:	Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:	We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.