exRNAdisease

Entry Detail

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General Information

Database ID: exR0269044 RNA Name: hsa-miR-424-5p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 134546680 End Site(bp): 134546701 External Links: hsa-miR-424-5p

Disease Information

Disease Name: Chronic Thromboembolic Pulmonary Hypertension Disease Category: Respiratory Tract Diseases MeSH ID: D006976 Type: Diseases Category/Respiratory Tract Diseases Alias: Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID: GSE138107 Description: Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA Experimental Design: Disease vs Control Case Disease Type: Chronic Thromboembolic Pulmonary Hypertension Case Disease SubType: NA Case Sample: Chronic Thromboembolic Pulmonary Hypertension Control Sample: Control Number of Case: 3 Number of Control: 3 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AADAT chr4 170060222 170091699 - ARRDC4 chr15 97960703 97973833 + ASB1 chr2 238426742 238452250 + ATXN2L chr16 28823035 28837237 + BACE1 chr11 117285207 117316259 - CASZ1 chr1 10636604 10796650 - DCAF7 chr17 63550477 63594279 + FAM102B chr1 108560089 108644900 + FLOT2 chr17 28879335 28897733 - JADE2 chr5 134524312 134583230 + KDSR chr18 63327726 63367228 - LITAF chr16 11547722 11636381 - LY6E chr8 143017982 143023832 + MAPKBP1 chr15 41774434 41827855 + MED11 chr17 4731428 4733607 + MINDY2 chr15 58771192 58861900 + MRPS2 chr9 135499984 135504673 + MYB chr6 135181308 135219173 + PRKAA1 chr5 40759379 40798374 - RAPGEF1 chr9 131576770 131740074 - RET chr10 43077064 43130351 + RTL8B chrX 135020513 135022542 - STEAP3 chr2 119223831 119265652 + TOB2 chr22 41433494 41446801 - ZNF664 chr12 123971845 124015439 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001005 chr2 53921020 53978078 - hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0000458 chr12 124071293 124074996 + hsa_circ_0001699 chr7 40027197 40041630 + hsa_circ_0001387 chr4 1902352 1936989 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0000552 chr14 71880664 71948928 + hsa_circ_0000038 chr1 28800065 28802803 + hsa_circ_0000652 chr15 90984737 90986710 + hsa_circ_0001472 chr5 36953719 36976504 + hsa_circ_0001263 chr3 5215701 5216099 + hsa_circ_0000799 chr17 65941524 65972074 + hsa_circ_0001164 chr20 45891031 45923523 - hsa_circ_0000032 chr1 25666964 25669564 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand NUTM2A-AS1 chr10 87201647 87342612 - LINC02035 chr3 122886941 122892416 + AC002470.2 chr22 20979462 20998121 + AC021092.1 chr19 44103007 44113183 - MCM3AP-AS1 chr21 46229196 46259390 + LINC00662 chr19 27681072 27794005 - MIR503HG chrX 134543119 134546642 - MIR497HG chr17 7015818 7019659 - AC079781.5 chr7 97851688 97972985 - STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + SNHG12 chr1 28578538 28583132 - AC009022.1 chr16 69976297 70065948 - LINC00649 chr21 33915534 33977691 + AP000317.2 chr21 34073592 34360033 + AL359924.1 chr1 237862175 237928321 + AC114980.1 chr5 93860669 93863825 - FGD5-AS1 chr3 14920347 14948424 - AL031282.2 chr1 1702736 1737688 - NUTM2B-AS1 chr10 79661394 79826594 - AL391244.1 chr1 1420245 1422691 + LINC01184 chr5 127939152 128083172 - XIST chrX 73820649 73852723 - HCG18 chr6 30286690 30327382 - SNHG16 chr17 76557764 76565348 + SNHG25 chr17 64145970 64146476 + SNHG1 chr11 62851984 62855953 - AC020978.7 chr16 68224713 68227734 + MZF1-AS1 chr19 58559129 58574797 + MIR29B2CHG chr1 207801518 207879115 - AC003092.1 chr7 94022833 94066661 + Display:

Experiment Detail

GEO ID: GSE138107 Sample Source: Blood Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 3 Num of detected RNAs of this Type: 359 Sample treatment protocol: Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis. RNA Extract protocol: total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum. RNA library preparation protocol: SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID: 31671920 Title: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Author: Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C Journal: Biomolecules. 2019 Oct 29;9(11). pii: E666. Description: We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.