exRNAdisease

General Information

Database ID:

exR0269084

RNA Name:

hsa-miR-625-5p

RNA Type:

miRNA

Chromosome:

chr14

Starnd:

Coordinate:

Start Site(bp):

65471116

End Site(bp):

65471136

External Links:

Disease Information

Disease Name:	Chronic Thromboembolic Pulmonary Hypertension
Disease Category:	Respiratory Tract Diseases
MeSH ID:	D006976
Type:	Diseases Category/Respiratory Tract Diseases
Alias:	Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID:	GSE138107
Description:	Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:	Disease vs Control
Case Disease Type:	Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:	NA
Case Sample:	Chronic Thromboembolic Pulmonary Hypertension
Control Sample:	Control
Number of Case:	3
Number of Control:	3
Number of Samples:	6

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
PPP2R1A	chr19	52190048	52229518	+
SF3B3	chr16	70523791	70577670	+
LRFN1	chr19	39306568	39315336	-
SLC6A6	chr3	14402576	14489349	+
VPS37B	chr12	122865330	122896127	-
SMARCC2	chr12	56162359	56189567	-
WIZ	chr19	15419978	15449956	-
SLC7A5	chr16	87830023	87869507	-
MED22	chr9	133338312	133348131	-
PPARD	chr6	35342558	35428191	+
FAM102A	chr9	127940582	127980989	-
ABL2	chr1	179099330	179229684	-
PPP6C	chr9	125146573	125189939	-
ABCF2	chr7	151207837	151227166	-
ABHD14A-ACY1	chr3	51974706	51989183	+
BCL9L	chr11	118893875	118925608	-
JUN	chr1	58780791	58784047	-
NUMB	chr14	73275107	73458617	-
SDF2	chr17	28648346	28662189	-
SREBF2	chr22	41833079	41907307	+
COL6A2	chr21	46098112	46132848	+
ACY1	chr3	51983340	51989197	+
E2F1	chr20	33675477	33686385	-
PRDX2	chr19	12796820	12801800	-
MSI1	chr12	120341330	120369164	-
COPS7B	chr2	231781671	231809254	+
CPSF7	chr11	61402641	61430031	-
SCAMP4	chr19	1905372	1926013	+
ITGA5	chr12	54395261	54419266	-
RNF44	chr5	176526712	176538025	-

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001434	chr4	106345352	106377902	-
hsa_circ_0001409	chr4	48835417	48859382	+
hsa_circ_0001358	chr3	169694733	169706147	+
hsa_circ_0001146	chr20	34241449	34246936	-

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC010542.4	chr16	66549280	66551189	+
AC145207.5	chr17	81878425	81881106	-
AC234582.1	chr1	155195004	155205495	+
H19	chr11	1995176	2001470	-
LINC00240	chr6	26956932	27059749	+
MALAT1	chr11	65497688	65506516	+
SNHG7	chr9	136721366	136728184	-
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE138107
Sample Source:	Blood
Source Fraction:	Exosome
Platform:	GPL18573
Method:	NGS
Num of detected RNA Type:	3
Num of detected RNAs of this Type:	359
Sample treatment protocol:	Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:	total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:	SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID:	31671920
Title:	Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:	Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:	Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:	We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.