exRNAdisease

Entry Detail

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General Information

Database ID: exR0269097 RNA Name: hsa-miR-769-5p RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 46018961 End Site(bp): 46018982 External Links: hsa-miR-769-5p

Disease Information

Disease Name: Chronic Thromboembolic Pulmonary Hypertension Disease Category: Respiratory Tract Diseases MeSH ID: D006976 Type: Diseases Category/Respiratory Tract Diseases Alias: Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID: GSE138107 Description: Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA Experimental Design: Disease vs Control Case Disease Type: Chronic Thromboembolic Pulmonary Hypertension Case Disease SubType: NA Case Sample: Chronic Thromboembolic Pulmonary Hypertension Control Sample: Control Number of Case: 3 Number of Control: 3 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACVR1B chr12 51951699 51997078 + ANGEL1 chr14 76786168 76826246 - ASB1 chr2 238426742 238452250 + BMPR2 chr2 202376327 202567751 + CAPNS1 chr19 36139953 36150353 + CBFB chr16 67028984 67101058 + CLDN11 chr3 170418865 170454733 + CLN8 chr8 1755778 1801711 + DBNDD1 chr16 90004871 90020128 - DCTN4 chr5 150708440 150759109 - EIF1AD chr11 65996545 66002176 - EIF1AX chrX 20124525 20141838 - FOXK1 chr7 4682295 4771442 + LONRF2 chr2 100271875 100322501 - MDM4 chr1 204516379 204558120 + MRTO4 chr1 19251805 19260128 + NUSAP1 chr15 41320794 41381050 + PLCD3 chr17 45108959 45133354 - PRKAA1 chr5 40759379 40798374 - PXN chr12 120210439 120265771 - RHPN1 chr8 143368876 143384221 + RUNX1 chr21 34787801 36004667 - TFAP4 chr16 4257186 4273075 - VAT1 chr17 43014607 43025123 - YPEL5 chr2 30146941 30160533 + ZDHHC9 chrX 129803288 129843909 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC245033.4 chr15 82533175 82540008 - LINC00324 chr17 8220642 8224043 - MALAT1 chr11 65497688 65506516 + SNHG1 chr11 62851984 62855953 - Display:

Experiment Detail

GEO ID: GSE138107 Sample Source: Blood Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 3 Num of detected RNAs of this Type: 359 Sample treatment protocol: Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis. RNA Extract protocol: total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum. RNA library preparation protocol: SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID: 31671920 Title: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Author: Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C Journal: Biomolecules. 2019 Oct 29;9(11). pii: E666. Description: We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.