Entry Detail


General Information

Database ID:exR0269098
RNA Name:hsa-miR-877-5p
RNA Type:miRNA
Chromosome:chr6
Starnd:+
Coordinate:
Start Site(bp):30584332End Site(bp):30584351
External Links:hsa-miR-877-5p



Disease Information

Disease Name:Chronic Thromboembolic Pulmonary Hypertension
Disease Category:Respiratory Tract Diseases
MeSH ID:D006976
Type:Diseases Category/Respiratory Tract Diseases
Alias:Hypertension, Pulmonary//Pulmonary Hypertension



Expression Detail

GEO ID:GSE138107
Description:Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:Disease vs Control
Case Disease Type:Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:NA
Case Sample:Chronic Thromboembolic Pulmonary Hypertension
Control Sample:Control
Number of Case:3
Number of Control:3
Number of Samples:6





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABR
chr17
1003518
1229738
-
DNAJB6
chr7
157335381
157417439
+
EIF2AK1
chr7
6022247
6059175
-
FOSL1
chr11
65892049
65900573
-
IGF2BP1
chr17
48997385
49056145
+
MAPK8IP2
chr22
50600793
50613981
+
PHTF2
chr7
77798792
77957503
+
PLD3
chr19
40348456
40380439
+
SMG1
chr16
18804853
18926454
-
TRAF7
chr16
2155698
2178129
+
USP54
chr10
73497538
73625953
-
ANAPC7
chr12
110372900
110403730
-
EIF4ENIF1
chr22
31436977
31496108
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC010442.1
chr5
466124
473098
-
AC092718.4
chr16
81030770
81031485
+
DNAAF4-CCPG1
chr15
55355248
55498360
-
DSCAM-AS1
chr21
40383083
40385358
+
LINC00910
chr17
43338741
43389199
-
LINC01278
chrX
63222993
63561095
-
NEAT1
chr11
65422774
65445540
+
SNHG16
chr17
76557764
76565348
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE138107
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:3
Num of detected RNAs of this Type:359
Sample treatment protocol:Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)



Reference

PMID:31671920
Title:Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.