exRNAdisease

Entry Detail

---



General Information

Database ID: exR0269385 RNA Name: hsa-miR-138-5p RNA Type: miRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 56858527 End Site(bp): 56858549 External Links: hsa-miR-138-5p

Disease Information

Disease Name: Multiple Sclerosis Disease Category: Nervous System Diseases MeSH ID: D009103 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Multiple//Sclerosis, Disseminated//Disseminated Sclerosis//MS (Multiple Sclerosis)//Multiple Sclerosis, Acute Fulminating

Expression Detail

GEO ID: GSE140106 Description: Serum exosome microRNAs predict multiple sclerosis disease activity after fingolimod treatment Experimental Design: Fingolimod treatment Case Disease Type: Multiple Sclerosis Case Disease SubType: NA Case Sample: Fingolimod treated Multiple Sclerosis Control Sample: Untreated Number of Case: 27 Number of Control: 27 Number of Samples: 54

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand KRT80 chr12 52168996 52192014 - STX3 chr11 59713456 59805882 + SIN3A chr15 75369379 75455842 - RNH1 chr11 494512 507300 - ACTN4 chr19 38647649 38731589 + CDCA7L chr7 21900899 21945903 - COPS7B chr2 231781671 231809254 + LARP4B chr10 806914 931705 - GSK3A chr19 42230190 42242625 - GNAI2 chr3 50226292 50259362 + NINJ1 chr9 93121496 93134251 - IGF2BP1 chr17 48997385 49056145 + TFAP2A chr6 10393186 10419659 - FOXC1 chr6 1609915 1613897 + PATL1 chr11 59636716 59669037 - SRF chr6 43171269 43181506 + MAFG chr17 81918270 81927735 - AHDC1 chr1 27534035 27604431 - FOXP4 chr6 41546426 41602384 + HIF1AN chr10 100529072 100559998 + PRKACA chr19 14091688 14118084 - SMG1 chr16 18804853 18926454 - IQGAP1 chr15 90388242 90502239 + CTDSP1 chr2 218398256 218405941 + HMGA1 chr6 34236873 34246231 + KLF11 chr2 10042849 10054836 + ZHX2 chr8 122781655 122974510 + IQSEC1 chr3 12897043 13283281 - PLXNB2 chr22 50274979 50307646 - TRIB1 chr8 125430358 125438403 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000402 chr12 53670403 53671011 + hsa_circ_0000798 chr17 65941524 65944422 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC092718.4 chr16 81030770 81031485 + AC144548.1 chr12 110387463 110445548 - AL137127.1 chr1 19072110 19075511 - H19 chr11 1995176 2001470 - MCF2L-AS1 chr13 112967484 112968824 - MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + PARD6G-AS1 chr18 80147924 80179839 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + TUG1 chr22 30969245 30979395 + TFAP2A-AS1 chr6 10409340 10416446 + Display:

Experiment Detail

GEO ID: GSE140106 Sample Source: Blood Source Fraction: Exosome Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1907 Sample treatment protocol: Exosomes were isolated from 1 mL RNase A (37 °C for 10 min; 100 ng/ml; Qiagen, Australia) treated serum, by size exclusion chromatography (qEV iZONE Science). RNA Extract protocol: Serum exosomes were processed for RNA extraction using the Plasma/Serum Circulating & Exosomal RNA Purification Mini Kit (Norgen Biotek, Cat. 51000) according to the manufacturer's protocol. RNA library preparation protocol: Exosome RNA sequencing libraries were then constructed using the NEBNext Multiplex Small RNA Library Prep Kit for Illumina (BioLabs, New England) according to the manufacturer's instructions.

Reference

PMID: 31721043 Title: Serum Exosome MicroRNAs Predict Multiple Sclerosis Disease Activity after Fingolimod Treatment Author: Ebrahimkhani S, Beadnall HN, Wang C, Suter CM, Barnett MH, Buckland ME, Vafaee F Journal: Mol Neurobiol. 2020 Feb;57(2):1245-1258. Description: we sought the possible utility of serum exosome microRNAs as biomarkers for disease activity in multiple sclerosis patients in response to fingolimod therapy.