exRNAdisease

Entry Detail

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General Information

Database ID: exR0269413 RNA Name: hsa-miR-151a-3p RNA Type: miRNA Chromosome: chr8 Starnd: - Coordinate: Start Site(bp): 140732587 End Site(bp): 140732607 External Links: hsa-miR-151a-3p

Disease Information

Disease Name: Multiple Sclerosis Disease Category: Nervous System Diseases MeSH ID: D009103 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Multiple//Sclerosis, Disseminated//Disseminated Sclerosis//MS (Multiple Sclerosis)//Multiple Sclerosis, Acute Fulminating

Expression Detail

GEO ID: GSE140106 Description: Serum exosome microRNAs predict multiple sclerosis disease activity after fingolimod treatment Experimental Design: Fingolimod treatment Case Disease Type: Multiple Sclerosis Case Disease SubType: NA Case Sample: Fingolimod treated Multiple Sclerosis Control Sample: Untreated Number of Case: 27 Number of Control: 27 Number of Samples: 54

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACP1 chr2 264140 278283 + PCDHA1 chr5 140786136 141012347 + PCDHA10 chr5 140855883 141012347 + PCDHA11 chr5 140868183 141012344 + PCDHA12 chr5 140875302 141012347 + PCDHA13 chr5 140882124 141012347 + PCDHA2 chr5 140794852 141012347 + PCDHA3 chr5 140801028 141012347 + PCDHA4 chr5 140806929 141012347 + PCDHA5 chr5 140821604 141012347 + PCDHA6 chr5 140827958 141012347 + PCDHA7 chr5 140834248 141012347 + PCDHA8 chr5 140841187 141012347 + PCDHA9 chr5 140847463 141012344 + PCDHAC1 chr5 140926369 141012344 + PCDHAC2 chr5 140966470 141012347 + STRBP chr9 123109500 123268586 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC044784.1 chr10 8970125 8973468 + AC104794.2 chr2 10083781 10086101 + AL160006.1 chr1 110058340 110062555 + SCARNA9 chr11 93721513 93721865 + TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE140106 Sample Source: Blood Source Fraction: Exosome Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1907 Sample treatment protocol: Exosomes were isolated from 1 mL RNase A (37 °C for 10 min; 100 ng/ml; Qiagen, Australia) treated serum, by size exclusion chromatography (qEV iZONE Science). RNA Extract protocol: Serum exosomes were processed for RNA extraction using the Plasma/Serum Circulating & Exosomal RNA Purification Mini Kit (Norgen Biotek, Cat. 51000) according to the manufacturer's protocol. RNA library preparation protocol: Exosome RNA sequencing libraries were then constructed using the NEBNext Multiplex Small RNA Library Prep Kit for Illumina (BioLabs, New England) according to the manufacturer's instructions.

Reference

PMID: 31721043 Title: Serum Exosome MicroRNAs Predict Multiple Sclerosis Disease Activity after Fingolimod Treatment Author: Ebrahimkhani S, Beadnall HN, Wang C, Suter CM, Barnett MH, Buckland ME, Vafaee F Journal: Mol Neurobiol. 2020 Feb;57(2):1245-1258. Description: we sought the possible utility of serum exosome microRNAs as biomarkers for disease activity in multiple sclerosis patients in response to fingolimod therapy.