exRNAdisease

Entry Detail

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General Information

Database ID: exR0269436 RNA Name: hsa-miR-181a-5p RNA Type: miRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 198859108 End Site(bp): 198859130 External Links: hsa-miR-181a-5p

Disease Information

Disease Name: Multiple Sclerosis Disease Category: Nervous System Diseases MeSH ID: D009103 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Multiple//Sclerosis, Disseminated//Disseminated Sclerosis//MS (Multiple Sclerosis)//Multiple Sclerosis, Acute Fulminating

Expression Detail

GEO ID: GSE140106 Description: Serum exosome microRNAs predict multiple sclerosis disease activity after fingolimod treatment Experimental Design: Fingolimod treatment Case Disease Type: Multiple Sclerosis Case Disease SubType: NA Case Sample: Fingolimod treated Multiple Sclerosis Control Sample: Untreated Number of Case: 27 Number of Control: 27 Number of Samples: 54

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CDKN1B chr12 12715058 12722369 + ETS1 chr11 128458761 128587558 - GALNT10 chr5 154190730 154420984 + IGF2BP3 chr7 23310209 23470491 - IRS2 chr13 109752695 109786583 - LAMC1 chr1 183023420 183145592 + NFIB chr9 14081843 14398983 - PPP1R3C chr10 91628442 91633071 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001550 chr5 167915606 167921655 + hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001522 chr5 122881110 122893258 + hsa_circ_0000892 chr19 11941431 12014514 + hsa_circ_0001361 chr3 171830241 171851336 + hsa_circ_0000931 chr19 38226804 38231095 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010442.1 chr5 466124 473098 - AC010655.4 chr7 128455840 128493859 + AC021078.1 chr5 149494314 149504670 - AC144548.1 chr12 110387463 110445548 - AL035458.2 chr20 34234840 34281173 - AL049543.1 chr6 28587378 28591747 + KCNQ1OT1 chr11 2608328 2699994 - LINC00667 chr18 5237826 5290608 + MALAT1 chr11 65497688 65506516 + MIR4458HG chr5 8450701 8486930 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + SNHG1 chr11 62851984 62855953 - SNHG5 chr6 85650491 85678932 - SNHG7 chr9 136721366 136728184 - THUMPD3-AS1 chr3 9349689 9398579 - XIST chrX 73820649 73852723 - ZSCAN16-AS1 chr6 28015122 28137293 - Display:

Experiment Detail

GEO ID: GSE140106 Sample Source: Blood Source Fraction: Exosome Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1907 Sample treatment protocol: Exosomes were isolated from 1 mL RNase A (37 °C for 10 min; 100 ng/ml; Qiagen, Australia) treated serum, by size exclusion chromatography (qEV iZONE Science). RNA Extract protocol: Serum exosomes were processed for RNA extraction using the Plasma/Serum Circulating & Exosomal RNA Purification Mini Kit (Norgen Biotek, Cat. 51000) according to the manufacturer's protocol. RNA library preparation protocol: Exosome RNA sequencing libraries were then constructed using the NEBNext Multiplex Small RNA Library Prep Kit for Illumina (BioLabs, New England) according to the manufacturer's instructions.

Reference

PMID: 31721043 Title: Serum Exosome MicroRNAs Predict Multiple Sclerosis Disease Activity after Fingolimod Treatment Author: Ebrahimkhani S, Beadnall HN, Wang C, Suter CM, Barnett MH, Buckland ME, Vafaee F Journal: Mol Neurobiol. 2020 Feb;57(2):1245-1258. Description: we sought the possible utility of serum exosome microRNAs as biomarkers for disease activity in multiple sclerosis patients in response to fingolimod therapy.