exRNAdisease

Entry Detail

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General Information

Database ID: exR0269531 RNA Name: hsa-miR-218-5p RNA Type: miRNA Chromosome: chr5 Starnd: - Coordinate: Start Site(bp): 168768211 End Site(bp): 168768231 External Links: hsa-miR-218-5p

Disease Information

Disease Name: Multiple Sclerosis Disease Category: Nervous System Diseases MeSH ID: D009103 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Multiple//Sclerosis, Disseminated//Disseminated Sclerosis//MS (Multiple Sclerosis)//Multiple Sclerosis, Acute Fulminating

Expression Detail

GEO ID: GSE140106 Description: Serum exosome microRNAs predict multiple sclerosis disease activity after fingolimod treatment Experimental Design: Fingolimod treatment Case Disease Type: Multiple Sclerosis Case Disease SubType: NA Case Sample: Fingolimod treated Multiple Sclerosis Control Sample: Untreated Number of Case: 27 Number of Control: 27 Number of Samples: 54

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABI2 chr2 203328239 203447728 + ADCY9 chr16 3953387 4116442 - CPA4 chr7 130293134 130324180 + GRK2 chr11 67266473 67286556 + IGF2 chr11 2129112 2141238 - LCLAT1 chr2 30447226 30644225 + LIN28B chr6 104936616 105083332 + OXSR1 chr3 38165089 38255484 + PARD6B chr20 50731580 50756795 + PRRC1 chr5 127517609 127555089 + RBBP9 chr20 18486540 18497225 - THUMPD1 chr16 20702816 20742084 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000798 chr17 65941524 65944422 + hsa_circ_0000155 chr1 168007608 168014465 + hsa_circ_0001452 chr4 153562079 153574079 - hsa_circ_0001860 chr9 37126308 37126939 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004069.1 chr4 105137280 105140619 - AC021092.1 chr19 44103007 44113183 - AC125257.1 chr17 41848518 41851447 - ADAMTSL4-AS1 chr1 150560202 150574552 - KCNQ1OT1 chr11 2608328 2699994 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + PSMA3-AS1 chr14 58265365 58298134 - Display:

Experiment Detail

GEO ID: GSE140106 Sample Source: Blood Source Fraction: Exosome Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1907 Sample treatment protocol: Exosomes were isolated from 1 mL RNase A (37 °C for 10 min; 100 ng/ml; Qiagen, Australia) treated serum, by size exclusion chromatography (qEV iZONE Science). RNA Extract protocol: Serum exosomes were processed for RNA extraction using the Plasma/Serum Circulating & Exosomal RNA Purification Mini Kit (Norgen Biotek, Cat. 51000) according to the manufacturer's protocol. RNA library preparation protocol: Exosome RNA sequencing libraries were then constructed using the NEBNext Multiplex Small RNA Library Prep Kit for Illumina (BioLabs, New England) according to the manufacturer's instructions.

Reference

PMID: 31721043 Title: Serum Exosome MicroRNAs Predict Multiple Sclerosis Disease Activity after Fingolimod Treatment Author: Ebrahimkhani S, Beadnall HN, Wang C, Suter CM, Barnett MH, Buckland ME, Vafaee F Journal: Mol Neurobiol. 2020 Feb;57(2):1245-1258. Description: we sought the possible utility of serum exosome microRNAs as biomarkers for disease activity in multiple sclerosis patients in response to fingolimod therapy.